Mechanistic principles of regulation by small RNAs

Publications

Unraveling the interplay between a small RNA and RNase E in bacteria

Barsheshet- Vigoda M., Argaman L., Kournos M., Margalit H.
Nucleic Acids Res. 2024 July 22:gkae621. doi: 10.1093/nar/gkae621.

RIL-seq reveals extensive involvement of small RNAs in virulence and capsule regulation in hypervirulent Klebsiella pneumoniae

Goh KJ., Altivia Y., Argaman L., Raz Y., Bar A., Lithgow T., Margalit H., Gan YH.
Nucleic Acids Res. 2024 May 28:gkae440. doi: 10.1093/nar/gkae440.

TRS: a method for determining transcript termini from RNAtag-seq sequencing data

Bar A., Argaman L., Eldar M., Margalit H.
Nat Commun. 2023 Nov 29;14(1):7843. doi: 10.1038/s41467-023-43534-2.

Inferring the contribution of small RNAs to changes in gene expression in response to stress

Barsheshet M, Fisher S and Margalit H.
NAR Genomics and Bioinformatics. 2022 Mar 4;4(1):lqac015. doi: 10.1093/nargab/lqac015. eCollection 2022 Mar.

Global RNA interactome of Salmonella discovers a 5' UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity

Matera G, Altuvia Y, Gerovac M, El Mouali Y, Margalit H, Vogel J
Molecular Cell. 2022 Feb 3;82(3):629-644.e4. doi: 10.1016/j.molcel.2021.12.030. Epub 2022 Jan 20. PMID: 35063132.

The impact of Hfq-mediated sRNA-mRNA interactome on the virulence of enteropathogenic Escherichia coli

Pearl Mizrahi S, Elbaz N, Argaman L, Altuvia Y, Katsowich N, Socol Y, Bar A, Rosenshine I and Margalit H.
Science Advances. 2021 Oct 29;7(44):eabi8228. doi: 10.1126/sciadv.abi8228. Epub 2021 Oct 27. PMID: 34705501.

Prediction of Novel Bacterial Small RNAs From RIL-Seq RNA-RNA Interaction Data

Bar A, Argaman L, Altuvia Y and Margalit H.
Frontiers in Microbiology. 2021 May 21;12:635070. doi: 10.3389/fmicb.2021.635070. PMID: 34093460; PMCID: PMC8175672.

Hierarchy in Hfq Chaperon Occupancy of Small RNA Targets Plays a Major Role in Their Regulation

Faigenbaum-Romm R, Reich A, Gatt YE, Barsheshet M, Argaman L and Margalit H.
Cell Reports. 2020 Mar 3;30(9):3127-3138.e6. doi: 10.1016/j.celrep.2020.02.016.