@article { WOS:000227407300035,
	title = {Relative predicted protein levels of functionally associated proteins are conserved across organisms},
	journal = {NUCLEIC ACIDS RESEARCH},
	volume = {33},
	number = {3},
	year = {2005},
	pages = {1051-1057},
	publisher = {OXFORD UNIV PRESS},
	type = {Article},
	address = {GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND},
	abstract = {We show that the predicted protein levels of functionally related proteins change in a coordinated fashion over many unicellular organisms. For each protein, we created a profile containing a protein abundance measure in each of a set of organisms. We show that for functionally related proteins these profiles tend to be correlated. Using the Codon Adaptation Index as a predictor of protein abundance in 48 unicellular organisms, we demonstrated this phenomenon for two types of functional relations: for proteins that physically interact and for proteins involved in consecutive steps within a metabolic pathway. Our results suggest that the protein abundance levels of functionally related proteins co-evolve.},
	issn = {0305-1048},
	doi = {10.1093/nar/gki261},
	url = {https://doi.org/10.1093/nar/gki261},
	author = {Lithwick, G and Margalit, H}
}
