Regulatory Circuits of Order 1 to 4
of Potential Biological Relevance


Detection of regulatory circuits by integrating the cellular networks of protein-protein interactions and transcription regulation
Yeger-Lotem, E. & Margalit, H. (2003) Nucleic Acids Res. 31, 60536061.

Legend

Circuit #: Protein A Protein B - the two proteins defining the circuit, Protein A is the regulator, gene B is the regulatee (we refer to a gene and the protein it encodes interchangeably).
   Transcription regulation path:  Series of regulator target interactions that leads from ProteinA to proteinB.
   Protein-protein interaction path: Series of physical protein-protein interactions that connects ProteinA with proteinB.
    Fraction of feasible interactions out of the total number of protein-protein interactions:  The fraction of interactions in the interaction path where the interacting pair-mates are co-localized,based on protein localization assessment.
   Co-localization path of physically interacting pair-mates: The localization path is ordered according to the order of the interactions in the interaction path. The localization of each interaction is separated by a <=>; If an interaction may occur in more than one cellular compartment, the compartments are separated by commas.
   Circuit significance based on cellular process assessment: The p-value based on Monte-Carlo analysis. 
   Common cellular processes: The cellular process(es) shared by the maximal number of circuit proteins.
   Circuit significance based on results of knockout experiments: The p-value of the chi-square test, testing the relationship between genes affected by the knockout of gene B and the gene targets of protein A.
   Circuit potential targets: List of genes that are direct regulatees of proteinA, and whose mRNA expression has changed at leat two-fold (up or down) in a proteinB deletion mutant.

Regulatory Circuits of Order 1

Circuit 1: Gal4 Gal80
   Transcription regulation path:  Gal4 --> Gal80
   Protein-protein interaction path: Gal4 <-> Gal80
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.047703
   Common cellular processes: Carbohydrate metabolism, Pol II transcription

Circuit 2: Swi6 Swi4
   Transcription regulation path:  Swi6 --> Swi4
   Protein-protein interaction path: Swi6 <-> Swi4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.047703
   Common cellular processes: Pol II transcription

Circuit 3: Ste12 Dig1
   Transcription regulation path:  Ste12 --> Dig1
   Protein-protein interaction path: Ste12 <-> Dig1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.004735
   Common cellular processes: Differentiation

Circuit 4: Cbf1 Met28
   Transcription regulation path:  Cbf1 --> Met28
   Protein-protein interaction path: Cbf1 <-> Met28
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.047703
   Common cellular processes: Amino-acid metabolism, Pol II transcription

Circuit 5: Ime1 Rim11
   Transcription regulation path:  Ime1 --> Rim11
   Protein-protein interaction path: Ime1 <-> Rim11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.005654
   Common cellular processes: Meiosis

Circuit 6: Met4 Met28
   Transcription regulation path:  Met4 --> Met28
   Protein-protein interaction path: Met4 <-> Met28
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.019435
   Common cellular processes: Amino-acid metabolism

Circuit 7: Rgt1 Std1
   Transcription regulation path:  Rgt1 --> Std1
   Protein-protein interaction path: Rgt1 <-> Std1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.009965
   Common cellular processes: Carbohydrate metabolism

Circuit 8: Dig1 Ste12
   Transcription regulation path:  Dig1 --> Ste12
   Protein-protein interaction path: Dig1 <-> Ste12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.004735
   Common cellular processes: Differentiation

Regulatory Circuits of Order 2

Circuit 9: Gcn4 Met4
   Transcription regulation path:  Gcn4 --> Met4
   Protein-protein interaction path: Gcn4 <-> Met31 <-> Met4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006065
   Common cellular processes: Amino-acid metabolism

Circuit 10: Gal4 Taf3
   Transcription regulation path:  Gal4 --> Mth1 --> Taf3
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Taf3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009848
   Common cellular processes: Pol II transcription

Circuit 11: Gal4 Gal3
   Transcription regulation path:  Gal4 --> Gal3
   Protein-protein interaction path: Gal4 <-> Gal80 <-> Gal3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Carbohydrate metabolism, Pol II transcription

Circuit 12: Gal4 Hta1
   Transcription regulation path:  Gal4 --> Hir2 --> Hta1
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009848
   Common cellular processes: Pol II transcription

Circuit 13: Swi6 Rad51
   Transcription regulation path:  Swi6 --> Rad51
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Rad51
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.005279
   Common cellular processes: DNA repair

Circuit 14: Mcm1 Hta1
   Transcription regulation path:  Mcm1 --> Swi4 --> Hta1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009848
   Common cellular processes: Pol II transcription

Circuit 15: Mcm1 Yap1
   Transcription regulation path:  Mcm1 --> Ace2 --> Yap1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009848
   Common cellular processes: Pol II transcription

Circuit 16: Ste12 Htb2
   Transcription regulation path:  Ste12 --> Htb2
   Protein-protein interaction path: Ste12 <-> Matalpha1 <-> Htb2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Pol II transcription

Circuit 17: Ste12 Fus3
   Transcription regulation path:  Ste12 --> Fus3
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Fus3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034427
   Common cellular processes: Differentiation, Mating response, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0022
   Circuit potential targets: Yil015c-a up, Prm5 up, Pgu1 up, Ktr2 up, Ylr042c up, Ddr48 up, Srl1 up.

Circuit 18: Ste12 Fus3
   Transcription regulation path:  Ste12 --> Fus3
   Protein-protein interaction path: Ste12 <-> Dig2 <-> Fus3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034427
   Common cellular processes: Differentiation, Mating response, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0022
   Circuit potential targets: Yil015c-a up, Prm5 up, Pgu1 up, Ktr2 up, Ylr042c up, Ddr48 up, Srl1 up.

Circuit 19: Tup1 Matalpha1
   Transcription regulation path:  Tup1 --> Matalpha1
   Protein-protein interaction path: Tup1 <-> Matalpha2 <-> Matalpha1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003426
   Common cellular processes: Mating response

Circuit 20: Hrt1 Cln1
   Transcription regulation path:  Hrt1 --> Cln1
   Protein-protein interaction path: Hrt1 <-> Cdc53 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.024486
   Common cellular processes: Cell cycle control, Differentiation

Circuit 21: Hrt1 Cln1
   Transcription regulation path:  Hrt1 --> Cln1
   Protein-protein interaction path: Hrt1 <-> Zpr1 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear, Nuclear transport factor<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.024486
   Common cellular processes: Cell cycle control, Differentiation

Circuit 22: Gln3 Arg1
   Transcription regulation path:  Gln3 --> Gcn4 --> Arg1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Arg1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022997
   Common cellular processes: Amino-acid metabolism

Circuit 23: Gln3 Arg4
   Transcription regulation path:  Gln3 --> Gcn4 --> Arg4
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Arg4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022997
   Common cellular processes: Amino-acid metabolism

Circuit 24: Gln3 Car1
   Transcription regulation path:  Gln3 --> Gcn4 --> Car1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022997
   Common cellular processes: Amino-acid metabolism

Circuit 25: Gln3 Cys4
   Transcription regulation path:  Gln3 --> Gcn4 --> Cys4
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Cys4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022997
   Common cellular processes: Amino-acid metabolism

Circuit 26: Gln3 Met17
   Transcription regulation path:  Gln3 --> Gcn4 --> Met17
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Met17
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022997
   Common cellular processes: Amino-acid metabolism

Circuit 27: Yap1 Ime1
   Transcription regulation path:  Yap1 --> Yap6 --> Ime1
   Protein-protein interaction path: Yap1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009848
   Common cellular processes: Pol II transcription

Circuit 28: Yap1 Cin5
   Transcription regulation path:  Yap1 --> Yap6 --> Cin5
   Protein-protein interaction path: Yap1 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009848
   Common cellular processes: Pol II transcription

Circuit 29: Yap1 Yap6
   Transcription regulation path:  Yap1 --> Yap6
   Protein-protein interaction path: Yap1 <-> Srb4 <-> Yap6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Pol II transcription

Circuit 30: Sin3 Ime1
   Transcription regulation path:  Sin3 --> Rme1 --> Ime1
   Protein-protein interaction path: Sin3 <-> Ume6 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000275
   Common cellular processes: Meiosis

Circuit 31: Spt6 Htb1
   Transcription regulation path:  Spt6 --> Htb1
   Protein-protein interaction path: Spt6 <-> Hht1 <-> Htb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001516
   Common cellular processes: Chromatin/chromosome structure

Circuit 32: Spt6 Htb1
   Transcription regulation path:  Spt6 --> Htb1
   Protein-protein interaction path: Spt6 <-> Hhf1 <-> Htb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001516
   Common cellular processes: Chromatin/chromosome structure

Circuit 33: Spt6 Hta1
   Transcription regulation path:  Spt6 --> Hta1
   Protein-protein interaction path: Spt6 <-> Hht1 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001516
   Common cellular processes: Chromatin/chromosome structure

Circuit 34: Spt6 Hta1
   Transcription regulation path:  Spt6 --> Hta1
   Protein-protein interaction path: Spt6 <-> Hhf1 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001516
   Common cellular processes: Chromatin/chromosome structure

Circuit 35: Mig1 Hir2
   Transcription regulation path:  Mig1 --> Gal4 --> Hir2
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Hir2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009848
   Common cellular processes: Pol II transcription

Circuit 36: Spt16 Lsm3
   Transcription regulation path:  Spt16 --> Swi4 --> Lsm3
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009188
   Common cellular processes: RNA processing/modification

Circuit 37: Spt16 Lsm4
   Transcription regulation path:  Spt16 --> Swi6 --> Lsm4
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009188
   Common cellular processes: RNA processing/modification

Circuit 38: Spt16 Lsm4
   Transcription regulation path:  Spt16 --> Swi4 --> Lsm4
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009188
   Common cellular processes: RNA processing/modification

Circuit 39: Rgt1 Hxt3
   Transcription regulation path:  Rgt1 --> Hxt3
   Protein-protein interaction path: Rgt1 <-> Std1 <-> Hxt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.001516
   Common cellular processes: Carbohydrate metabolism

Circuit 40: Skn7 Fks1
   Transcription regulation path:  Skn7 --> Sok2 --> Fks1
   Protein-protein interaction path: Skn7 <-> Rho1 <-> Fks1
   Circuit significance based on cellular process assessment: 0.001816
   Common cellular processes: Cell wall maintenance
   Circuit significance based on results of knockout experiments: 0.0218
   Circuit potential targets: Cis3 up, Cys3 up, Cwp2 up, Uth1 up, Ahp1 up, Zwf1 up.

Circuit 41: Ume6 Ime1
   Transcription regulation path:  Ume6 --> Rme1 --> Ime1
   Protein-protein interaction path: Ume6 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.002797
   Common cellular processes: Meiosis

Circuit 42: Mbp1 Swi4
   Transcription regulation path:  Mbp1 --> Swi4
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Swi4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Pol II transcription

Circuit 43: Cin5 Ime1
   Transcription regulation path:  Cin5 --> Ime1
   Protein-protein interaction path: Cin5 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Pol II transcription

Circuit 44: Cin5 Yap6
   Transcription regulation path:  Cin5 --> Yap6
   Protein-protein interaction path: Cin5 <-> Srb4 <-> Yap6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Pol II transcription

Circuit 45: Stb1 Cln2
   Transcription regulation path:  Stb1 --> Cln2
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.024486
   Common cellular processes: Cell cycle control

Circuit 46: Stb1 Clb2
   Transcription regulation path:  Stb1 --> Ndd1 --> Clb2
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Clb2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006767
   Common cellular processes: Cell cycle control

Circuit 47: Stb1 Cln1
   Transcription regulation path:  Stb1 --> Ndd1 --> Cln1
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.006767
   Common cellular processes: Cell cycle control

Circuit 48: Yap6 Cin5
   Transcription regulation path:  Yap6 --> Cin5
   Protein-protein interaction path: Yap6 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Pol II transcription

Circuit 49: Yap6 Aca1
   Transcription regulation path:  Yap6 --> Aca1
   Protein-protein interaction path: Yap6 <-> Gts1 <-> Aca1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Cell stress, Pol II transcription

Circuit 50: Yap6 Ime1
   Transcription regulation path:  Yap6 --> Ime1
   Protein-protein interaction path: Yap6 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013422
   Common cellular processes: Pol II transcription

Regulatory Circuits of Order 3

Circuit 51: Gcn4 Met18
   Transcription regulation path:  Gcn4 --> Yap5 --> Met18
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Med11 <-> Met18
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 52: Gcn4 Ace2
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Ace2
   Protein-protein interaction path: Gcn4 <-> Ngg1 <-> Sua7 <-> Ace2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 53: Gcn4 Ace2
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Ace2
   Protein-protein interaction path: Gcn4 <-> Spt15 <-> Sua7 <-> Ace2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 54: Gcn4 Yn51_yeast
   Transcription regulation path:  Gcn4 --> Yn51_yeast
   Protein-protein interaction path: Gcn4 <-> Cdc4 <-> Skp1 <-> Yn51_yeast
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.048379
   Common cellular processes: Amino-acid metabolism, Cell cycle control

Circuit 55: Gcn4 Cln1
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Cln1
   Protein-protein interaction path: Gcn4 <-> Cdc4 <-> Cdc53 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.006692
   Common cellular processes: Cell cycle control

Circuit 56: Gcn4 Met28
   Transcription regulation path:  Gcn4 --> Met28
   Protein-protein interaction path: Gcn4 <-> Met31 <-> Met4 <-> Met28
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000304
   Common cellular processes: Amino-acid metabolism

Circuit 57: Gcn4 Cln2
   Transcription regulation path:  Gcn4 --> Stb1 --> Cln2
   Protein-protein interaction path: Gcn4 <-> Cdc4 <-> Cdc53 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.014247
   Common cellular processes: Cell cycle control

Circuit 58: Gcn4 Dbf2
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Dbf2
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Pop2 <-> Dbf2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 59: Gcn4 Ahc1
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Ahc1
   Protein-protein interaction path: Gcn4 <-> Ada2 <-> Ahc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 60: Gal4 Hxt3
   Transcription regulation path:  Gal4 --> Mth1 --> Hxt3
   Protein-protein interaction path: Gal4 <-> Spt15 <-> Std1 <-> Hxt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.002028
   Common cellular processes: Carbohydrate metabolism

Circuit 61: Gal4 Taf8
   Transcription regulation path:  Gal4 --> Taf8
   Protein-protein interaction path: Gal4 <-> Spt15 <-> Taf10 <-> Taf8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004053
   Common cellular processes: Pol II transcription

Circuit 62: Gal4 Taf8
   Transcription regulation path:  Gal4 --> Taf8
   Protein-protein interaction path: Gal4 <-> Ada2 <-> Taf10 <-> Taf8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004053
   Common cellular processes: Pol II transcription

Circuit 63: Swi5 Gas1
   Transcription regulation path:  Swi5 --> Ash1 --> Gas1
   Protein-protein interaction path: Swi5 <-> Msn5 <-> Nup116 <-> Gas1
   Circuit significance based on cellular process assessment: 0.014247
   Common cellular processes: Cell cycle control
   Circuit significance based on results of knockout experiments: 0.0223
   Circuit potential targets: Pst1 up, Crh1 up, Yhb1 down, Yhr138c up, Hsp150 up, Pir3 up, Ylr194c up, Chs1 up, Yn09_yeast down.

Circuit 64: Swi5 Gdh3
   Transcription regulation path:  Swi5 --> Gdh3
   Protein-protein interaction path: Swi5 <-> Dmc1 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.038501
   Common cellular processes: Cell cycle control

Circuit 65: Swi6 Srp1
   Transcription regulation path:  Swi6 --> Abf1 --> Srp1
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Srp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006084
   Common cellular processes: Chromatin/chromosome structure, DNA synthesis

Circuit 66: Swi6 Clb1
   Transcription regulation path:  Swi6 --> Swi4 --> Clb1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Clb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.001166
   Common cellular processes: Cell cycle control

Circuit 67: Swi6 Cln1
   Transcription regulation path:  Swi6 --> Cln1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000152
   Common cellular processes: Cell cycle control

Circuit 68: Swi6 Cln1
   Transcription regulation path:  Swi6 --> Cln1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000152
   Common cellular processes: Cell cycle control

Circuit 69: Swi6 Cln1
   Transcription regulation path:  Swi6 --> Cln1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000152
   Common cellular processes: Cell cycle control

Circuit 70: Swi6 Lsm4
   Transcription regulation path:  Swi6 --> Lsm4
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Dcp1 <-> Lsm4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.038804
   Common cellular processes: RNA processing/modification

Circuit 71: Swi6 Cln3
   Transcription regulation path:  Swi6 --> Swi4 --> Cln3
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.001166
   Common cellular processes: Cell cycle control

Circuit 72: Swi6 Cln3
   Transcription regulation path:  Swi6 --> Swi4 --> Cln3
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.001166
   Common cellular processes: Cell cycle control

Circuit 73: Swi6 Cln3
   Transcription regulation path:  Swi6 --> Swi4 --> Cln3
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.001166
   Common cellular processes: Cell cycle control

Circuit 74: Swi6 Cdc7
   Transcription regulation path:  Swi6 --> Cdc7
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cdc7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 75: Swi6 Sic1
   Transcription regulation path:  Swi6 --> Ndd1 --> Swi5 --> Sic1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Sic1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000101
   Common cellular processes: Cell cycle control

Circuit 76: Swi6 Cdc34
   Transcription regulation path:  Swi6 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Grr1 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000760
   Common cellular processes: Cell cycle control

Circuit 77: Swi6 Cdc34
   Transcription regulation path:  Swi6 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000760
   Common cellular processes: Cell cycle control

Circuit 78: Swi6 Crz1
   Transcription regulation path:  Swi6 --> Abf1 --> Pho2 --> Crz1
   Protein-protein interaction path: Swi6 <-> Mbp1 <-> Skn7 <-> Crz1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 79: Swi6 Spo13
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Spo13
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Pfs1 <-> Spo13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001572
   Common cellular processes: Meiosis

Circuit 80: Swi6 Cdc24
   Transcription regulation path:  Swi6 --> Abf1 --> Cdc24
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cdc24
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.014247
   Common cellular processes: Cell cycle control

Circuit 81: Swi6 Cdc6
   Transcription regulation path:  Swi6 --> Swi4 --> Cdc6
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Cdc6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001166
   Common cellular processes: Cell cycle control

Circuit 82: Swi6 Clb3
   Transcription regulation path:  Swi6 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.000760
   Common cellular processes: Cell cycle control

Circuit 83: Swi6 Clb3
   Transcription regulation path:  Swi6 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cks1 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.000760
   Common cellular processes: Cell cycle control

Circuit 84: Mcm1 Tfa2
   Transcription regulation path:  Mcm1 --> Swi5 --> Rme1 --> Tfa2
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Gal11 <-> Tfa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 85: Mcm1 Tfa2
   Transcription regulation path:  Mcm1 --> Ace2 --> Rme1 --> Tfa2
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Gal11 <-> Tfa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 86: Mcm1 Sir3
   Transcription regulation path:  Mcm1 --> Ace2 --> Yap1 --> Sir3
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Hta1 <-> Sir3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 87: Mcm1 Ahc1
   Transcription regulation path:  Mcm1 --> Swi4 --> Ndd1 --> Ahc1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ada2 <-> Ahc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 88: Mcm1 Taf12
   Transcription regulation path:  Mcm1 --> Swi5 --> Rme1 --> Taf12
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 89: Mcm1 Taf12
   Transcription regulation path:  Mcm1 --> Ace2 --> Rme1 --> Taf12
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 90: Mcm1 Taf12
   Transcription regulation path:  Mcm1 --> Swi5 --> Rme1 --> Taf12
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ada2 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 91: Mcm1 Taf12
   Transcription regulation path:  Mcm1 --> Ace2 --> Rme1 --> Taf12
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ada2 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 92: Mcm1 Spt8
   Transcription regulation path:  Mcm1 --> Swi4 --> Spt8
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Spt8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 93: Mcm1 Spt8
   Transcription regulation path:  Mcm1 --> Swi4 --> Spt8
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ada2 <-> Spt8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 94: Mcm1 Met18
   Transcription regulation path:  Mcm1 --> Swi5 --> Met18
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Med11 <-> Met18
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 95: Mcm1 Htb2
   Transcription regulation path:  Mcm1 --> Swi4 --> Spt21 --> Htb2
   Protein-protein interaction path: Mcm1 <-> Matalpha1 <-> Htb2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 96: Mcm1 Hhf1
   Transcription regulation path:  Mcm1 --> Swi4 --> Spt21 --> Hhf1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Hta1 <-> Hhf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 97: Mcm1 Ime1
   Transcription regulation path:  Mcm1 --> Swi5 --> Rme1 --> Ime1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 98: Mcm1 Ime1
   Transcription regulation path:  Mcm1 --> Ace2 --> Rme1 --> Ime1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 99: Mcm1 Ime1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Ime1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 100: Mcm1 Pdr1
   Transcription regulation path:  Mcm1 --> Swi4 --> Pdr1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Pdr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 101: Mcm1 Sin4
   Transcription regulation path:  Mcm1 --> Swi4 --> Pdr1 --> Sin4
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Gal11 <-> Sin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 102: Mcm1 Tra1
   Transcription regulation path:  Mcm1 --> Tra1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Tra1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004053
   Common cellular processes: Pol II transcription

Circuit 103: Mcm1 Tra1
   Transcription regulation path:  Mcm1 --> Tra1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ada2 <-> Tra1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004053
   Common cellular processes: Pol II transcription

Circuit 104: Mcm1 Yap6
   Transcription regulation path:  Mcm1 --> Ace2 --> Yap1 --> Yap6
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 105: Mcm1 Yap6
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Yap6
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 106: Ste12 Hem13
   Transcription regulation path:  Ste12 --> Mss11 --> Rox1 --> Hem13
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Hem13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation

Circuit 107: Ste12 Fus1
   Transcription regulation path:  Ste12 --> Fus1
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste7 <-> Fus1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.000355
   Common cellular processes: Mating response

Circuit 108: Ste12 Ime1
   Transcription regulation path:  Ste12 --> Swi5 --> Rme1 --> Ime1
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001724
   Common cellular processes: Pol II transcription

Circuit 109: Ste12 Cin5
   Transcription regulation path:  Ste12 --> Cup9 --> Yap6 --> Cin5
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 110: Ste12 Rad51
   Transcription regulation path:  Ste12 --> Rad51
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Rad51
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017477
   Common cellular processes: Differentiation

Circuit 111: Ste12 Cvt19
   Transcription regulation path:  Ste12 --> Cvt19
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Cvt19
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.017477
   Common cellular processes: Differentiation

Circuit 112: Ste12 Yps1
   Transcription regulation path:  Ste12 --> Yps1
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Yps1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017477
   Common cellular processes: Differentiation, Protein degradation

Circuit 113: Abf1 Cop1
   Transcription regulation path:  Abf1 --> Cop1
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Cop1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002178
   Common cellular processes: Pol III transcription

Circuit 114: Cbf1 Cdc34
   Transcription regulation path:  Cbf1 --> Reb1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Cbf1 <-> Met4 <-> Met30 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009936
   Common cellular processes: Amino-acid metabolism

Circuit 115: Cbf1 Smx3
   Transcription regulation path:  Cbf1 --> Reb1 --> Smx3
   Protein-protein interaction path: Cbf1 <-> Mcm21 <-> Srp1 <-> Smx3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006084
   Common cellular processes: Chromatin/chromosome structure

Circuit 116: Cbf1 Lsm3
   Transcription regulation path:  Cbf1 --> Reb1 --> Swi5 --> Lsm3
   Protein-protein interaction path: Cbf1 <-> Mcm21 <-> Smb1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001166
   Common cellular processes: Chromatin/chromosome structure

Circuit 117: Cbf1 Met17
   Transcription regulation path:  Cbf1 --> Met17
   Protein-protein interaction path: Cbf1 <-> Mcm21 <-> Srp1 <-> Met17
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.048379
   Common cellular processes: Amino-acid metabolism, Chromatin/chromosome structure

Circuit 118: Gln3 Sfl1
   Transcription regulation path:  Gln3 --> Gcn4 --> Stb1 --> Sfl1
   Protein-protein interaction path: Gln3 <-> Gts1 <-> Sfl1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006619
   Common cellular processes: Pol II transcription

Circuit 119: Gln3 Utp6
   Transcription regulation path:  Gln3 --> Gcn4 --> Yap5 --> Utp6
   Protein-protein interaction path: Gln3 <-> Gts1 <-> Lys14 <-> Utp6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 120: Gal11 Matalpha1
   Transcription regulation path:  Gal11 --> Matalpha1
   Protein-protein interaction path: Gal11 <-> Srb4 <-> Mcm1 <-> Matalpha1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004053
   Common cellular processes: Pol II transcription

Circuit 121: Yap1 Sen2
   Transcription regulation path:  Yap1 --> Sen2
   Protein-protein interaction path: Yap1 <-> Nup116 <-> Sen54 <-> Sen2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.038804
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 122: Yap1 Lsm3
   Transcription regulation path:  Yap1 --> Lsm3
   Protein-protein interaction path: Yap1 <-> Crm1 <-> Dcp1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.038804
   Common cellular processes: RNA processing/modification

Circuit 123: Yap1 Lsm3
   Transcription regulation path:  Yap1 --> Lsm3
   Protein-protein interaction path: Yap1 <-> Nup116 <-> Dcp1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.038804
   Common cellular processes: RNA processing/modification

Circuit 124: Yap1 Nmd5
   Transcription regulation path:  Yap1 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Yap1 <-> Crm1 <-> Nup1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.028997
   Common cellular processes: Cell stress

Circuit 125: Yap1 Nmd5
   Transcription regulation path:  Yap1 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Yap1 <-> Crm1 <-> Nup159 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.028997
   Common cellular processes: Cell stress

Circuit 126: Yap1 Nmd5
   Transcription regulation path:  Yap1 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Yap1 <-> Kap95 <-> Nup1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.028997
   Common cellular processes: Cell stress

Circuit 127: Yap1 Nmd5
   Transcription regulation path:  Yap1 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Yap1 <-> Kap95 <-> Nup159 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.028997
   Common cellular processes: Cell stress

Circuit 128: Yap1 Red1
   Transcription regulation path:  Yap1 --> Rox1 --> Ume6 --> Red1
   Protein-protein interaction path: Yap1 <-> Nup116 <-> Smt3 <-> Red1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.044206
   Common cellular processes: Meiosis

Circuit 129: Ace2 Cin5
   Transcription regulation path:  Ace2 --> Yap1 --> Yap6 --> Cin5
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 130: Ace2 Lsm3
   Transcription regulation path:  Ace2 --> Lsm3
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Dcp1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.038804
   Common cellular processes: RNA processing/modification

Circuit 131: Ace2 Taf12
   Transcription regulation path:  Ace2 --> Rme1 --> Taf12
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Spt15 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 132: Ace2 Taf12
   Transcription regulation path:  Ace2 --> Rme1 --> Taf12
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Ngg1 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 133: Ace2 Taf12
   Transcription regulation path:  Ace2 --> Rme1 --> Taf12
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Spt20 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 134: Sin3 Rim11
   Transcription regulation path:  Sin3 --> Rme1 --> Ime1 --> Rim11
   Protein-protein interaction path: Sin3 <-> Ume6 <-> Rim11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000505
   Common cellular processes: Meiosis

Circuit 135: Swi4 Cln1
   Transcription regulation path:  Swi4 --> Cln1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 136: Swi4 Cln1
   Transcription regulation path:  Swi4 --> Cln1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Far1 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 137: Swi4 Cln1
   Transcription regulation path:  Swi4 --> Cln1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc53 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 138: Swi4 Cln1
   Transcription regulation path:  Swi4 --> Cln1
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 139: Swi4 Gin4
   Transcription regulation path:  Swi4 --> Gin4
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Nap1 <-> Gin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.038501
   Common cellular processes: Cell cycle control

Circuit 140: Swi4 Cla4
   Transcription regulation path:  Swi4 --> Cla4
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Cla4
   Circuit significance based on cellular process assessment: 0.038501
   Common cellular processes: Cell cycle control
   Circuit significance based on results of knockout experiments: 0.0382
   Circuit potential targets: Cln2 up.

Circuit 141: Swi4 Cla4
   Transcription regulation path:  Swi4 --> Cla4
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Cla4
   Circuit significance based on cellular process assessment: 0.038501
   Common cellular processes: Cell cycle control
   Circuit significance based on results of knockout experiments: 0.0382
   Circuit potential targets: Cln2 up.

Circuit 142: Swi4 Bmh1
   Transcription regulation path:  Swi4 --> Bmh1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Ste20 <-> Bmh1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.017477
   Common cellular processes: Differentiation, Signal transduction

Circuit 143: Swi4 Clb3
   Transcription regulation path:  Swi4 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.006692
   Common cellular processes: Cell cycle control

Circuit 144: Swi4 Clb3
   Transcription regulation path:  Swi4 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cks1 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.006692
   Common cellular processes: Cell cycle control

Circuit 145: Swi4 Clb3
   Transcription regulation path:  Swi4 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.006692
   Common cellular processes: Cell cycle control

Circuit 146: Swi4 Clb3
   Transcription regulation path:  Swi4 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cks1 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.006692
   Common cellular processes: Cell cycle control

Circuit 147: Swi4 Cdc6
   Transcription regulation path:  Swi4 --> Cdc6
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Cdc6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 148: Swi4 Cdc6
   Transcription regulation path:  Swi4 --> Cdc6
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Cdc6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 149: Swi4 Cln3
   Transcription regulation path:  Swi4 --> Cln3
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 150: Swi4 Cln3
   Transcription regulation path:  Swi4 --> Cln3
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Far1 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 151: Swi4 Cln3
   Transcription regulation path:  Swi4 --> Cln3
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc53 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 152: Swi4 Cln3
   Transcription regulation path:  Swi4 --> Cln3
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 153: Swi4 Sic1
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Sic1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Sic1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000760
   Common cellular processes: Cell cycle control

Circuit 154: Swi4 Sic1
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Sic1
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Sic1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000760
   Common cellular processes: Cell cycle control

Circuit 155: Swi4 Hog1
   Transcription regulation path:  Swi4 --> Hog1
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Ptp2 <-> Hog1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.011145
   Common cellular processes: Cell stress, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0268
   Circuit potential targets: Mnn1 down, Msb2 up, Cwp1 down, Spt8 up, Gat2 up, Aga1 up.

Circuit 156: Swi4 Hog1
   Transcription regulation path:  Swi4 --> Hog1
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Ptp3 <-> Hog1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011145
   Common cellular processes: Cell stress, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0268
   Circuit potential targets: Mnn1 down, Msb2 up, Cwp1 down, Spt8 up, Gat2 up, Aga1 up.

Circuit 157: Swi4 Clb1
   Transcription regulation path:  Swi4 --> Clb1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Clb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 158: Swi4 Clb1
   Transcription regulation path:  Swi4 --> Clb1
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Clb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.003090
   Common cellular processes: Cell cycle control

Circuit 159: Swi4 Cdc34
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Grr1 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006692
   Common cellular processes: Cell cycle control

Circuit 160: Swi4 Cdc34
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc53 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006692
   Common cellular processes: Cell cycle control

Circuit 161: Mig1 Lsm3
   Transcription regulation path:  Mig1 --> Swi5 --> Lsm3
   Protein-protein interaction path: Mig1 <-> Cus1 <-> Brr2 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001065
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 162: Mig1 Cat8
   Transcription regulation path:  Mig1 --> Cat8
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Std1 <-> Cat8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000304
   Common cellular processes: Carbohydrate metabolism

Circuit 163: Mig1 Tps1
   Transcription regulation path:  Mig1 --> Tps1
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup1 <-> Tps1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011145
   Common cellular processes: Carbohydrate metabolism, Cell stress

Circuit 164: Mig1 Prp22
   Transcription regulation path:  Mig1 --> Gal4 --> Prp22
   Protein-protein interaction path: Mig1 <-> Mud2 <-> Msl5 <-> Prp22
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000507
   Common cellular processes: RNA splicing

Circuit 165: Mig1 Prp22
   Transcription regulation path:  Mig1 --> Gal4 --> Prp22
   Protein-protein interaction path: Mig1 <-> Mud2 <-> Clf1 <-> Prp22
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000507
   Common cellular processes: RNA splicing

Circuit 166: Mig1 Hxt3
   Transcription regulation path:  Mig1 --> Gal4 --> Mth1 --> Hxt3
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Std1 <-> Hxt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.000051
   Common cellular processes: Carbohydrate metabolism

Circuit 167: Mig1 Ntc20
   Transcription regulation path:  Mig1 --> Gal4 --> Ntc20
   Protein-protein interaction path: Mig1 <-> Mud2 <-> Clf1 <-> Ntc20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000507
   Common cellular processes: RNA splicing

Circuit 168: Spt16 Prp8
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Prp8
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Snu114 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.002433
   Common cellular processes: RNA processing/modification

Circuit 169: Spt16 Prp8
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Prp8
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm3 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002433
   Common cellular processes: RNA processing/modification

Circuit 170: Spt16 Gsp1
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Gsp1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Yrb1 <-> Gsp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.036196
   Common cellular processes: Cell cycle control

Circuit 171: Spt16 Dhh1
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Dhh1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Dhh1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.002433
   Common cellular processes: RNA processing/modification

Circuit 172: Spt16 Crm1
   Transcription regulation path:  Spt16 --> Swi6 --> Crm1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Dcp1 <-> Crm1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.020229
   Common cellular processes: RNA processing/modification, RNA turnover

Circuit 173: Spt16 Prp4
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Prp4
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm7 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002433
   Common cellular processes: RNA processing/modification

Circuit 174: Spt16 Prp4
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Prp4
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm3 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002433
   Common cellular processes: RNA processing/modification

Circuit 175: Spt16 Hog1
   Transcription regulation path:  Spt16 --> Swi4 --> Hog1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Ste11 <-> Hog1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.044920
   Common cellular processes: Mating response, RNA turnover, Signal transduction

Circuit 176: Phd1 Sps18
   Transcription regulation path:  Phd1 --> Ste12 --> Mss11 --> Sps18
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Nup116 <-> Sps18
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation

Circuit 177: Phd1 Nup42
   Transcription regulation path:  Phd1 --> Hap4 --> Nup42
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Nup42
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.020736
   Common cellular processes: Energy generation

Circuit 178: Phd1 Yap1
   Transcription regulation path:  Phd1 --> Yap1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Nup116 <-> Yap1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017477
   Common cellular processes: Differentiation

Circuit 179: Phd1 Hop1
   Transcription regulation path:  Phd1 --> Ime1 --> Hop1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Red1 <-> Hop1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002079
   Common cellular processes: Meiosis

Circuit 180: Phd1 Kap104
   Transcription regulation path:  Phd1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Nup116 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation

Circuit 181: Phd1 Dig1
   Transcription regulation path:  Phd1 --> Ste12 --> Dig1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Dig1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011154
   Common cellular processes: Differentiation

Circuit 182: Phd1 Bmh1
   Transcription regulation path:  Phd1 --> Msn2 --> Bmh1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Bmh1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.011154
   Common cellular processes: Differentiation

Circuit 183: Phd1 Qcr2
   Transcription regulation path:  Phd1 --> Hap4 --> Qcr2
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Qcr2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.020736
   Common cellular processes: Energy generation
   Circuit significance based on results of knockout experiments: 0.003
   Circuit potential targets: Tip20 down, Git1 down, Wsc4 down, Cis3 up, Hrc198 down, Kkq1_yeast up, Pry2 up, Hxt2 up, Spo20 down, Gat2 down, Scw10 up, Ygp1 up.

Circuit 184: Skn7 Ime2
   Transcription regulation path:  Skn7 --> Sok2 --> Ime1 --> Ime2
   Protein-protein interaction path: Skn7 <-> Mbp1 <-> Swi6 <-> Ime2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 185: Skn7 Ime2
   Transcription regulation path:  Skn7 --> Nrg1 --> Ime1 --> Ime2
   Protein-protein interaction path: Skn7 <-> Mbp1 <-> Swi6 <-> Ime2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 186: Ume6 Rim11
   Transcription regulation path:  Ume6 --> Rme1 --> Ime1 --> Rim11
   Protein-protein interaction path: Ume6 <-> Rim11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 1/1
   Co-localization path of physically interacting pair-mates:  Nuclear
   Circuit significance based on cellular process assessment: 0.000665
   Common cellular processes: Meiosis

Circuit 187: Ume6 Mer1
   Transcription regulation path:  Ume6 --> Mer1
   Protein-protein interaction path: Ume6 <-> Rim11 <-> Srb4 <-> Mer1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010638
   Common cellular processes: Meiosis

Circuit 188: Ume6 Mlp2
   Transcription regulation path:  Ume6 --> Hsf1 --> Reb1 --> Mlp2
   Protein-protein interaction path: Ume6 <-> Nup116 <-> Kap95 <-> Mlp2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.005374
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 189: Ume6 Lsm3
   Transcription regulation path:  Ume6 --> Rme1 --> Lsm3
   Protein-protein interaction path: Ume6 <-> Sin3 <-> Lsm4 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002079
   Common cellular processes: Meiosis

Circuit 190: Ume6 Mrpl4
   Transcription regulation path:  Ume6 --> Rme1 --> Mrpl4
   Protein-protein interaction path: Ume6 <-> Sin3 <-> Snp1 <-> Mrpl4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.002079
   Common cellular processes: Meiosis

Circuit 191: Ume6 Sub1
   Transcription regulation path:  Ume6 --> Hsf1 --> Reb1 --> Sub1
   Protein-protein interaction path: Ume6 <-> Ime1 <-> Srb4 <-> Sub1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.034624
   Common cellular processes: Pol II transcription

Circuit 192: Ume6 Mek1
   Transcription regulation path:  Ume6 --> Mek1
   Protein-protein interaction path: Ume6 <-> Sin3 <-> Stb5 <-> Mek1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000709
   Common cellular processes: Meiosis

Circuit 193: Ume6 Red1
   Transcription regulation path:  Ume6 --> Red1
   Protein-protein interaction path: Ume6 <-> Nup116 <-> Smt3 <-> Red1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010638
   Common cellular processes: Meiosis

Circuit 194: Pre2 Swi5
   Transcription regulation path:  Pre2 --> Fkh2 --> Swi5
   Protein-protein interaction path: Pre2 <-> Hmo1 <-> Msn5 <-> Swi5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.014247
   Common cellular processes: Cell cycle control

Circuit 195: Pre2 Hxt3
   Transcription regulation path:  Pre2 --> Gcn4 --> Cyc8 --> Hxt3
   Protein-protein interaction path: Pre2 <-> Std1 <-> Hxt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.001290
   Common cellular processes: Small molecule transport

Circuit 196: Pre2 Gdh3
   Transcription regulation path:  Pre2 --> Fkh2 --> Swi5 --> Gdh3
   Protein-protein interaction path: Pre2 <-> Hmo1 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.036196
   Common cellular processes: Cell cycle control

Circuit 197: Pre2 Gdh3
   Transcription regulation path:  Pre2 --> Fkh2 --> Swi5 --> Gdh3
   Protein-protein interaction path: Pre2 <-> Smt3 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.036196
   Common cellular processes: Cell cycle control

Circuit 198: Mbp1 Cnb1
   Transcription regulation path:  Mbp1 --> Abf1 --> Cnb1
   Protein-protein interaction path: Mbp1 <-> Skn7 <-> Cna1 <-> Cnb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.001420
   Common cellular processes: Pol II transcription

Circuit 199: Stb1 Bbp1
   Transcription regulation path:  Stb1 --> Bbp1
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.038501
   Common cellular processes: Cell cycle control

Circuit 200: Stb1 Cdc6
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Cdc6
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cdc6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003253
   Common cellular processes: Cell cycle control

Circuit 201: Stb1 Sic1
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Sic1
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Sic1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.003253
   Common cellular processes: Cell cycle control

Circuit 202: Gcr2 Prp21
   Transcription regulation path:  Gcr2 --> Prp21
   Protein-protein interaction path: Gcr2 <-> Lsm4 <-> Prp11 <-> Prp21
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006332
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 203: Dig1 Kap104
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup57 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 204: Dig1 Kap104
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup42 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation

Circuit 205: Dig1 Kap104
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup49 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 206: Dig1 Kap104
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup100 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 207: Dig1 Kap104
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup116 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 208: Dig1 Kap104
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup1 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 209: Dig1 Kap104
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Prp45 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation

Circuit 210: Dig1 Spo12
   Transcription regulation path:  Dig1 --> Ste12 --> Spo12
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Mcm21 <-> Spo12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011154
   Common cellular processes: Differentiation

Circuit 211: Dig1 Spo12
   Transcription regulation path:  Dig1 --> Hrt1 --> Spo12
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Mcm21 <-> Spo12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011154
   Common cellular processes: Differentiation

Circuit 212: Dig1 Crm1
   Transcription regulation path:  Dig1 --> Crm1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Gsp1 <-> Crm1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008663
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 213: Dig1 Crm1
   Transcription regulation path:  Dig1 --> Crm1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup57 <-> Crm1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008663
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 214: Dig1 Crm1
   Transcription regulation path:  Dig1 --> Crm1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup49 <-> Crm1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008663
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 215: Dig1 Crm1
   Transcription regulation path:  Dig1 --> Crm1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup100 <-> Crm1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008663
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 216: Dig1 Crm1
   Transcription regulation path:  Dig1 --> Crm1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup116 <-> Crm1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008663
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 217: Dig1 Crm1
   Transcription regulation path:  Dig1 --> Crm1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup1 <-> Crm1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008663
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 218: Dig1 Smk1
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Smk1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Qcr2 <-> Smk1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.027324
   Common cellular processes: Differentiation

Circuit 219: Dig1 Smd2
   Transcription regulation path:  Dig1 --> Smd2
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Smx3 <-> Smd2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.038804
   Common cellular processes: Chromatin/chromosome structure, DNA synthesis, RNA processing/modification, RNA splicing

Circuit 220: Dig1 Rad54
   Transcription regulation path:  Dig1 --> Rad54
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Rad51 <-> Rad54
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.029990
   Common cellular processes: Chromatin/chromosome structure, DNA repair, Recombination

Circuit 221: Dig1 Myo4
   Transcription regulation path:  Dig1 --> Ste12 --> Myo4
   Protein-protein interaction path: Dig1 <-> Srp1 <-> She2 <-> Myo4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.011154
   Common cellular processes: Differentiation

Circuit 222: Dig1 Fus1
   Transcription regulation path:  Dig1 --> Fus1
   Protein-protein interaction path: Dig1 <-> Kss1 <-> Ste7 <-> Fus1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.003647
   Common cellular processes: Mating response

Circuit 223: Dig1 Fus1
   Transcription regulation path:  Dig1 --> Fus1
   Protein-protein interaction path: Dig1 <-> Fus3 <-> Ste7 <-> Fus1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.003647
   Common cellular processes: Mating response

Regulatory Circuits of Order 4

Circuit 224: Gcn4 Stb1
   Transcription regulation path:  Gcn4 --> Stb1
   Protein-protein interaction path: Gcn4 <-> Cdc4 <-> Cdc6 <-> Cdc28 <-> Stb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Cell cycle control

Circuit 225: Gcn4 Cyc8
   Transcription regulation path:  Gcn4 --> Cyc8
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Mcm1 <-> Matalpha2 <-> Cyc8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 226: Gcn4 Sfl1
   Transcription regulation path:  Gcn4 --> Stb1 --> Sfl1
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Yap6 <-> Gts1 <-> Sfl1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 227: Gcn4 Sfl1
   Transcription regulation path:  Gcn4 --> Stb1 --> Sfl1
   Protein-protein interaction path: Gcn4 <-> Taf5 <-> Yap6 <-> Gts1 <-> Sfl1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 228: Gcn4 Utp6
   Transcription regulation path:  Gcn4 --> Yap5 --> Utp6
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Yap6 <-> Lys14 <-> Utp6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 229: Gcn4 Utp6
   Transcription regulation path:  Gcn4 --> Yap5 --> Utp6
   Protein-protein interaction path: Gcn4 <-> Taf5 <-> Yap6 <-> Lys14 <-> Utp6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 230: Gcn4 Rsp5
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Ace2 --> Rsp5
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Gal11 <-> Rpo21 <-> Rsp5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.004607
   Common cellular processes: Pol II transcription

Circuit 231: Gcn4 Rsp5
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Ace2 --> Rsp5
   Protein-protein interaction path: Gcn4 <-> Srb2 <-> Gal11 <-> Rpo21 <-> Rsp5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.004607
   Common cellular processes: Pol II transcription

Circuit 232: Gcn4 Rsp5
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Ace2 --> Rsp5
   Protein-protein interaction path: Gcn4 <-> Srb7 <-> Gal11 <-> Rpo21 <-> Rsp5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.004607
   Common cellular processes: Pol II transcription

Circuit 233: Gcn4 Sic1
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Swi5 --> Sic1
   Protein-protein interaction path: Gcn4 <-> Cdc4 <-> Cdc6 <-> Cdc28 <-> Sic1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 234: Gcn4 Clb2
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Clb2
   Protein-protein interaction path: Gcn4 <-> Cdc4 <-> Cdc6 <-> Cdc28 <-> Clb2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control
   Circuit significance based on results of knockout experiments: 0.0001
   Circuit potential targets: Lys2 up, Sfa1 up, His7 up, Rib5 up, His4 up, Lys20 up, Yhm1 up, Ar56_yeast up, Trp2 up, Met13 up, Apg1 up, Pcl5 up, His5 up, Lys1 up, Bna1 up, Cpa2 up, Yj81_yeast up, Ecm40 up, Ilv2 up, Leu4 up, Arg1 up, Met22 up, Mch4 up, Ort1 up, Tea1 up, Icy2 up, Ymc1 up, Met16 up.

Circuit 235: Gcn4 Yap1
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Ace2 --> Yap1
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Yap1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.005211
   Common cellular processes: Pol II transcription

Circuit 236: Gcn4 Caf16
   Transcription regulation path:  Gcn4 --> Caf16
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Pop2 <-> Mob1 <-> Caf16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 237: Gcn4 Sen2
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Sen2
   Protein-protein interaction path: Gcn4 <-> Srb4 <-> Yap6 <-> Lys14 <-> Sen2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 238: Gcn4 Sen2
   Transcription regulation path:  Gcn4 --> Stb1 --> Ndd1 --> Sen2
   Protein-protein interaction path: Gcn4 <-> Taf5 <-> Yap6 <-> Lys14 <-> Sen2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 239: Gal4 Dam1
   Transcription regulation path:  Gal4 --> Dam1
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Yap6 <-> Lys14 <-> Dam1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 240: Gal4 Hir2
   Transcription regulation path:  Gal4 --> Hir2
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Rsc8 <-> Snf2 <-> Hir2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 241: Gal4 Cha4
   Transcription regulation path:  Gal4 --> Cha4
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Yap6 <-> Lys14 <-> Cha4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 242: Gal4 Rpc31
   Transcription regulation path:  Gal4 --> Rpc31
   Protein-protein interaction path: Gal4 <-> Spt15 <-> Brf1 <-> Rpc34 <-> Rpc31
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Pol III transcription

Circuit 243: Gal4 Sfl1
   Transcription regulation path:  Gal4 --> Sfl1
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Yap6 <-> Gts1 <-> Sfl1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 244: Gal4 Hsh49
   Transcription regulation path:  Gal4 --> Hsh49
   Protein-protein interaction path: Gal4 <-> Ada2 <-> Pcf11 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification

Circuit 245: Gal4 Ntc20
   Transcription regulation path:  Gal4 --> Ntc20
   Protein-protein interaction path: Gal4 <-> Ada2 <-> Prp40 <-> Clf1 <-> Ntc20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 246: Gal4 Kap104
   Transcription regulation path:  Gal4 --> Kap104
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Crm1 <-> Nup1 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 247: Gal4 Kap104
   Transcription regulation path:  Gal4 --> Kap104
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Crm1 <-> Nup57 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 248: Gal4 Kap104
   Transcription regulation path:  Gal4 --> Kap104
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Crm1 <-> Nup49 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 249: Gal4 Kap104
   Transcription regulation path:  Gal4 --> Kap104
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Crm1 <-> Nup100 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 250: Gal4 Kap104
   Transcription regulation path:  Gal4 --> Kap104
   Protein-protein interaction path: Gal4 <-> Srb4 <-> Crm1 <-> Nup116 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 251: Pho4 Lsm3
   Transcription regulation path:  Pho4 --> Lsm3
   Protein-protein interaction path: Pho4 <-> Gsp1 <-> Crm1 <-> Dcp1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification

Circuit 252: Pho4 Lsm3
   Transcription regulation path:  Pho4 --> Lsm3
   Protein-protein interaction path: Pho4 <-> Gsp1 <-> Yrb1 <-> Lsm1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification

Circuit 253: Pho4 Crz1
   Transcription regulation path:  Pho4 --> Crz1
   Protein-protein interaction path: Pho4 <-> Msn5 <-> Nup1 <-> Nmd5 <-> Crz1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.014089
   Common cellular processes: Cell stress, Nuclear-cytoplasmic transport

Circuit 254: Pho4 Cdc4
   Transcription regulation path:  Pho4 --> Cdc4
   Protein-protein interaction path: Pho4 <-> Gsp1 <-> Cse1 <-> Cdc16 <-> Cdc4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Cell cycle control

Circuit 255: Swi5 Bni1
   Transcription regulation path:  Swi5 --> Bni1
   Protein-protein interaction path: Swi5 <-> Pcl2 <-> Rvs167 <-> Act1 <-> Bni1
   Circuit significance based on cellular process assessment: 0.008022
   Common cellular processes: Cell polarity
   Circuit significance based on results of knockout experiments: 0.0072
   Circuit potential targets: Gpr1 down, Yel076w-c down.

Circuit 256: Swi5 Tps3
   Transcription regulation path:  Swi5 --> Tps3
   Protein-protein interaction path: Swi5 <-> Msn5 <-> Nup1 <-> Tps1 <-> Tps3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.014089
   Common cellular processes: Carbohydrate metabolism, Cell stress

Circuit 257: Swi5 Rpl16b
   Transcription regulation path:  Swi5 --> Gat3 --> Rpl16b
   Protein-protein interaction path: Swi5 <-> Msn5 <-> Nup57 <-> Sxm1 <-> Rpl16b
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 258: Swi5 Rpl16b
   Transcription regulation path:  Swi5 --> Gat3 --> Rpl16b
   Protein-protein interaction path: Swi5 <-> Msn5 <-> Nup1 <-> Sxm1 <-> Rpl16b
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 259: Swi5 Rpl16b
   Transcription regulation path:  Swi5 --> Gat3 --> Rpl16b
   Protein-protein interaction path: Swi5 <-> Msn5 <-> Nup100 <-> Sxm1 <-> Rpl16b
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 260: Swi5 Rpl16b
   Transcription regulation path:  Swi5 --> Gat3 --> Rpl16b
   Protein-protein interaction path: Swi5 <-> Msn5 <-> Nup116 <-> Sxm1 <-> Rpl16b
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 261: Swi6 Rsr1
   Transcription regulation path:  Swi6 --> Swi4 --> Rsr1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Ste20 <-> Cdc24 <-> Rsr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic<=> Cytoskeletal<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.005364
   Common cellular processes: Cell polarity

Circuit 262: Swi6 Sgt1
   Transcription regulation path:  Swi6 --> Abf1 --> Sgt1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Grr1 <-> Skp1 <-> Sgt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004913
   Common cellular processes: Cell cycle control

Circuit 263: Swi6 Sgt1
   Transcription regulation path:  Swi6 --> Abf1 --> Sgt1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cdc4 <-> Sgt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Centrosome/spindle pole body, Nuclear
   Circuit significance based on cellular process assessment: 0.004913
   Common cellular processes: Cell cycle control

Circuit 264: Swi6 Sgt1
   Transcription regulation path:  Swi6 --> Abf1 --> Sgt1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Skp1 <-> Sgt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004913
   Common cellular processes: Cell cycle control

Circuit 265: Swi6 Car1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Car1
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.028520
   Common cellular processes: Chromatin/chromosome structure, DNA synthesis

Circuit 266: Swi6 Prp8
   Transcription regulation path:  Swi6 --> Abf1 --> Prp8
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Dcp1 <-> Lsm8 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification

Circuit 267: Swi6 Prp8
   Transcription regulation path:  Swi6 --> Abf1 --> Prp8
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Dcp1 <-> Lsm3 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification

Circuit 268: Swi6 Prp8
   Transcription regulation path:  Swi6 --> Abf1 --> Prp8
   Protein-protein interaction path: Swi6 <-> Slt2 <-> Smd3 <-> Lsm8 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 269: Swi6 Gbp2
   Transcription regulation path:  Swi6 --> Abf1 --> Gbp2
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Srp1 <-> Gbp2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002005
   Common cellular processes: Chromatin/chromosome structure

Circuit 270: Swi6 Zpr1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Hsf1 --> Zpr1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 271: Swi6 Zpr1
   Transcription regulation path:  Swi6 --> Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 272: Swi6 Zpr1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Hsf1 --> Zpr1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 273: Swi6 Zpr1
   Transcription regulation path:  Swi6 --> Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 274: Swi6 Zpr1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Hsf1 --> Zpr1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 275: Swi6 Zpr1
   Transcription regulation path:  Swi6 --> Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 276: Swi6 Rck1
   Transcription regulation path:  Swi6 --> Swi4 --> Sok2 --> Rck1
   Protein-protein interaction path: Swi6 <-> Slt2 <-> Ptp2 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.002256
   Common cellular processes: Signal transduction

Circuit 277: Swi6 Rck1
   Transcription regulation path:  Swi6 --> Swi4 --> Sok2 --> Rck1
   Protein-protein interaction path: Swi6 <-> Slt2 <-> Ptp3 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.002256
   Common cellular processes: Signal transduction

Circuit 278: Swi6 Gin4
   Transcription regulation path:  Swi6 --> Gin4
   Protein-protein interaction path: Swi6 <-> Swi4 <-> Clb2 <-> Nap1 <-> Gin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Cell cycle control

Circuit 279: Swi6 Dmc1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Rad51 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008771
   Common cellular processes: DNA repair, Meiosis

Circuit 280: Swi6 Qcr2
   Transcription regulation path:  Swi6 --> Abf1 --> Qcr2
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Srp1 <-> Qcr2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.015891
   Common cellular processes: Chromatin/chromosome structure, DNA synthesis

Circuit 281: Swi6 Cop1
   Transcription regulation path:  Swi6 --> Abf1 --> Cop1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Met30 <-> Cop1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.042761
   Common cellular processes: Amino-acid metabolism, Cell cycle control

Circuit 282: Swi6 Cct8
   Transcription regulation path:  Swi6 --> Abf1 --> Cct8
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cdc24 <-> Cct8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Cytoskeletal
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 283: Swi6 Kin3
   Transcription regulation path:  Swi6 --> Ndd1 --> Kin3
   Protein-protein interaction path: Swi6 <-> Pet123 <-> Apg17 <-> Tem1 <-> Kin3
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control
   Circuit significance based on results of knockout experiments: 0.0124
   Circuit potential targets: Kkq1_yeast up, Pry2 up, Svs1 up.

Circuit 284: Swi6 Kin3
   Transcription regulation path:  Swi6 --> Ndd1 --> Kin3
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Tem1 <-> Kin3
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control
   Circuit significance based on results of knockout experiments: 0.0124
   Circuit potential targets: Kkq1_yeast up, Pry2 up, Svs1 up.

Circuit 285: Swi6 Rfa2
   Transcription regulation path:  Swi6 --> Rfa2
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Rad51 <-> Rad52 <-> Rfa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000050
   Common cellular processes: DNA repair

Circuit 286: Swi6 Abf1
   Transcription regulation path:  Swi6 --> Abf1
   Protein-protein interaction path: Swi6 <-> Slt2 <-> Smd3 <-> Rad16 <-> Abf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.007471
   Common cellular processes: Chromatin/chromosome structure

Circuit 287: Swi6 Gsp1
   Transcription regulation path:  Swi6 --> Abf1 --> Gsp1
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Rad51 <-> Srp1 <-> Gsp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 288: Swi6 Gsp1
   Transcription regulation path:  Swi6 --> Abf1 --> Gsp1
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Srp1 <-> Gsp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control, Chromatin/chromosome structure, DNA synthesis, RNA processing/modification

Circuit 289: Swi6 Tos2
   Transcription regulation path:  Swi6 --> Swi4 --> Tos2
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cdc24 <-> Tos2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Bud neck
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 290: Swi6 Tif5
   Transcription regulation path:  Swi6 --> Ndd1 --> Tif5
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Rad51 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 291: Swi6 Tif5
   Transcription regulation path:  Swi6 --> Ndd1 --> Tif5
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 292: Swi6 Bbp1
   Transcription regulation path:  Swi6 --> Ndd1 --> Swi5 --> Ash1 --> Bbp1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 293: Swi6 Bbp1
   Transcription regulation path:  Swi6 --> Ndd1 --> Swi5 --> Ash1 --> Bbp1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 294: Swi6 Bbp1
   Transcription regulation path:  Swi6 --> Ndd1 --> Swi5 --> Ash1 --> Bbp1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 295: Swi6 Ydj1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Hsf1 --> Ydj1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc28 <-> Cln3 <-> Ydj1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.020431
   Common cellular processes: Cell cycle control

Circuit 296: Swi6 Ydj1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Hsf1 --> Ydj1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cln3 <-> Ydj1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.020431
   Common cellular processes: Cell cycle control

Circuit 297: Swi6 Ydj1
   Transcription regulation path:  Swi6 --> Abf1 --> Ume6 --> Hsf1 --> Ydj1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Cln3 <-> Ydj1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.020431
   Common cellular processes: Cell cycle control

Circuit 298: Swi6 Swe1
   Transcription regulation path:  Swi6 --> Swe1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Far1 <-> Cdc24 <-> Swe1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Bud neck, Nuclear
   Circuit significance based on cellular process assessment: 0.000702
   Common cellular processes: Cell cycle control

Circuit 299: Swi6 Swe1
   Transcription regulation path:  Swi6 --> Swe1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Met30 <-> Swe1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000702
   Common cellular processes: Cell cycle control

Circuit 300: Swi6 Prp4
   Transcription regulation path:  Swi6 --> Abf1 --> Prp4
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Dcp1 <-> Lsm8 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification

Circuit 301: Swi6 Prp4
   Transcription regulation path:  Swi6 --> Abf1 --> Prp4
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Dcp1 <-> Lsm7 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification

Circuit 302: Swi6 Prp4
   Transcription regulation path:  Swi6 --> Abf1 --> Prp4
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Dcp1 <-> Lsm3 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification

Circuit 303: Swi6 Prp4
   Transcription regulation path:  Swi6 --> Abf1 --> Prp4
   Protein-protein interaction path: Swi6 <-> Slt2 <-> Smd3 <-> Lsm8 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 304: Swi6 Prp4
   Transcription regulation path:  Swi6 --> Abf1 --> Prp4
   Protein-protein interaction path: Swi6 <-> Slt2 <-> Smd3 <-> Snu66 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 305: Swi6 Cnb1
   Transcription regulation path:  Swi6 --> Abf1 --> Cnb1
   Protein-protein interaction path: Swi6 <-> Mbp1 <-> Skn7 <-> Cna1 <-> Cnb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 306: Swi6 Gdh3
   Transcription regulation path:  Swi6 --> Ndd1 --> Gdh3
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Rad51 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 307: Swi6 Gdh3
   Transcription regulation path:  Swi6 --> Ndd1 --> Gdh3
   Protein-protein interaction path: Swi6 <-> Ime2 <-> Smx3 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 308: Swi6 Bdf1
   Transcription regulation path:  Swi6 --> Abf1 --> Bdf1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Grr1 <-> Skp1 <-> Bdf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004913
   Common cellular processes: Cell cycle control

Circuit 309: Swi6 Bdf1
   Transcription regulation path:  Swi6 --> Abf1 --> Bdf1
   Protein-protein interaction path: Swi6 <-> Cln2 <-> Cdc53 <-> Skp1 <-> Bdf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004913
   Common cellular processes: Cell cycle control

Circuit 310: Swi6 Zip1
   Transcription regulation path:  Swi6 --> Abf1 --> Zip1
   Protein-protein interaction path: Swi6 <-> Hrr25 <-> Rad51 <-> Cst9 <-> Zip1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002958
   Common cellular processes: Meiosis, Recombination

Circuit 311: Mcm1 Hog1
   Transcription regulation path:  Mcm1 --> Swi4 --> Hog1
   Protein-protein interaction path: Mcm1 <-> Ste12 <-> Kss1 <-> Ste11 <-> Hog1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.003208
   Common cellular processes: Mating response, Signal transduction
   Circuit significance based on results of knockout experiments: 0.007
   Circuit potential targets: Chs2 up, Mfa1 up, Aga2 up, Hsp150 up, Car2 up, Aga1 up.

Circuit 312: Mcm1 Swi5
   Transcription regulation path:  Mcm1 --> Swi5
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Nup84 <-> Msn5 <-> Swi5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Cell cycle control, Mating response

Circuit 313: Mcm1 Pcf11
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ada2 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 314: Mcm1 Hsp104
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Msn4 --> Hsp104
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap1 <-> Nup116 <-> Hsp104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 315: Mcm1 Zpr1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Cin5 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 316: Mcm1 Sfl1
   Transcription regulation path:  Mcm1 --> Swi5 --> Sfl1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap6 <-> Gts1 <-> Sfl1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 317: Mcm1 Sfl1
   Transcription regulation path:  Mcm1 --> Ace2 --> Sfl1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap6 <-> Gts1 <-> Sfl1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 318: Mcm1 Aca1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Aca1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap6 <-> Gts1 <-> Aca1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 319: Mcm1 Cin5
   Transcription regulation path:  Mcm1 --> Ace2 --> Yap1 --> Yap6 --> Cin5
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.005211
   Common cellular processes: Pol II transcription

Circuit 320: Mcm1 Cin5
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Yap6 --> Cin5
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.005211
   Common cellular processes: Pol II transcription

Circuit 321: Mcm1 Yng1
   Transcription regulation path:  Mcm1 --> Swi5 --> Ash1 --> Hap4 --> Yng1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Gal4 <-> Sua7 <-> Yng1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000300
   Common cellular processes: Pol II transcription

Circuit 322: Mcm1 Yng1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Hap4 --> Yng1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Gal4 <-> Sua7 <-> Yng1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000300
   Common cellular processes: Pol II transcription

Circuit 323: Mcm1 Yng1
   Transcription regulation path:  Mcm1 --> Swi5 --> Ash1 --> Hap4 --> Yng1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Sua7 <-> Yng1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000300
   Common cellular processes: Pol II transcription

Circuit 324: Mcm1 Yng1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Hap4 --> Yng1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Sua7 <-> Yng1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000300
   Common cellular processes: Pol II transcription

Circuit 325: Mcm1 Yng1
   Transcription regulation path:  Mcm1 --> Swi5 --> Ash1 --> Hap4 --> Yng1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Med6 <-> Sua7 <-> Yng1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000300
   Common cellular processes: Pol II transcription

Circuit 326: Mcm1 Yng1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Hap4 --> Yng1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Med6 <-> Sua7 <-> Yng1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000300
   Common cellular processes: Pol II transcription

Circuit 327: Mcm1 Bfr2
   Transcription regulation path:  Mcm1 --> Swi5 --> Ash1 --> Hap4 --> Bfr2
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Lcp5 <-> Bfr2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 328: Mcm1 Bfr2
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Hap4 --> Bfr2
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Lcp5 <-> Bfr2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 329: Mcm1 Rsp5
   Transcription regulation path:  Mcm1 --> Ace2 --> Rsp5
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Gal11 <-> Rpo21 <-> Rsp5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 330: Mcm1 Tom1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Msn4 --> Tom1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ngg1 <-> Tom1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 331: Mcm1 Pse1
   Transcription regulation path:  Mcm1 --> Swi4 --> Pse1
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Nup84 <-> Nup57 <-> Pse1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 332: Mcm1 Pse1
   Transcription regulation path:  Mcm1 --> Swi4 --> Pse1
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Nup84 <-> Nup145 <-> Pse1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 333: Mcm1 Pse1
   Transcription regulation path:  Mcm1 --> Swi4 --> Pse1
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Nup84 <-> Nup49 <-> Pse1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 334: Mcm1 Pse1
   Transcription regulation path:  Mcm1 --> Swi4 --> Pse1
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Nup84 <-> Nup100 <-> Pse1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 335: Mcm1 Pse1
   Transcription regulation path:  Mcm1 --> Swi4 --> Pse1
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Nup84 <-> Nup116 <-> Pse1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 336: Mcm1 Tps1
   Transcription regulation path:  Mcm1 --> Swi4 --> Sok2 --> Msn4 --> Tps1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Ckb2 <-> Top2 <-> Tps1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 337: Mcm1 Rpn1
   Transcription regulation path:  Mcm1 --> Ace2 --> Yap1 --> Rpn4 --> Rpn1
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Gal4 <-> Rpt6 <-> Rpn1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Endoplasmatic reticulum, Nuclear
   Circuit significance based on cellular process assessment: 0.000300
   Common cellular processes: Pol II transcription

Circuit 338: Mcm1 Dal80
   Transcription regulation path:  Mcm1 --> Swi5 --> Gat1 --> Dal80
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Tup1 <-> Hda1 <-> Dal80
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 339: Mcm1 Dal80
   Transcription regulation path:  Mcm1 --> Ace2 --> Gat1 --> Dal80
   Protein-protein interaction path: Mcm1 <-> Matalpha2 <-> Tup1 <-> Hda1 <-> Dal80
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 340: Mcm1 Sen2
   Transcription regulation path:  Mcm1 --> Ace2 --> Yap1 --> Sen2
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap6 <-> Lys14 <-> Sen2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 341: Mcm1 Sen2
   Transcription regulation path:  Mcm1 --> Swi4 --> Ndd1 --> Sen2
   Protein-protein interaction path: Mcm1 <-> Srb4 <-> Yap6 <-> Lys14 <-> Sen2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 342: Pdr1 Sin4
   Transcription regulation path:  Pdr1 --> Sin4
   Protein-protein interaction path: Pdr1 <-> Ngg1 <-> Srb4 <-> Gal11 <-> Sin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 343: Pdr1 Sin4
   Transcription regulation path:  Pdr1 --> Sin4
   Protein-protein interaction path: Pdr1 <-> Ngg1 <-> Srb2 <-> Gal11 <-> Sin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 344: Pdr1 Sin4
   Transcription regulation path:  Pdr1 --> Sin4
   Protein-protein interaction path: Pdr1 <-> Ngg1 <-> Srb7 <-> Gal11 <-> Sin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 345: Spt15 Cln2
   Transcription regulation path:  Spt15 --> Cln2
   Protein-protein interaction path: Spt15 <-> Gcn4 <-> Cdc4 <-> Cdc53 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Amino-acid metabolism, Cell cycle control

Circuit 346: Ste12 Rck1
   Transcription regulation path:  Ste12 --> Rck1
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste11 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Signal transduction

Circuit 347: Ste12 Ime2
   Transcription regulation path:  Ste12 --> Mss11 --> Rox1 --> Ume6 --> Ime2
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Smx3 <-> Ime2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.047972
   Common cellular processes: Differentiation

Circuit 348: Ste12 Mer1
   Transcription regulation path:  Ste12 --> Swi5 --> Rme1 --> Ime1 --> Mer1
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Mer1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 349: Ste12 Taf9
   Transcription regulation path:  Ste12 --> Taf9
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Gcn4 <-> Taf9
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 350: Ste12 Taf9
   Transcription regulation path:  Ste12 --> Taf9
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Ngg1 <-> Taf9
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 351: Ste12 Taf9
   Transcription regulation path:  Ste12 --> Taf9
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Ada2 <-> Taf9
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 352: Ste12 Taf14
   Transcription regulation path:  Ste12 --> Sum1 --> Taf14
   Protein-protein interaction path: Ste12 <-> Matalpha1 <-> Htb1 <-> Snf5 <-> Taf14
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 353: Ste12 Kap104
   Transcription regulation path:  Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup57 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 354: Ste12 Kap104
   Transcription regulation path:  Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup42 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 355: Ste12 Kap104
   Transcription regulation path:  Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup49 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 356: Ste12 Kap104
   Transcription regulation path:  Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup100 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 357: Ste12 Kap104
   Transcription regulation path:  Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup116 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 358: Ste12 Kap104
   Transcription regulation path:  Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup1 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation, Nuclear-cytoplasmic transport

Circuit 359: Ste12 Kap104
   Transcription regulation path:  Ste12 --> Sum1 --> Kap104
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Prp45 <-> Kap104
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 360: Ste12 Nmd5
   Transcription regulation path:  Ste12 --> Cup9 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.025839
   Common cellular processes: Cell stress

Circuit 361: Ste12 Sps18
   Transcription regulation path:  Ste12 --> Mss11 --> Sps18
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Nup116 <-> Sps18
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 362: Ste12 Cpr6
   Transcription regulation path:  Ste12 --> Cpr6
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste11 <-> Hsp82 <-> Cpr6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response, Signal transduction

Circuit 363: Ste12 Cpr6
   Transcription regulation path:  Ste12 --> Cpr6
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste11 <-> Hsc82 <-> Cpr6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response, Signal transduction

Circuit 364: Ste12 Myo4
   Transcription regulation path:  Ste12 --> Myo4
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> She2 <-> Myo4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.003911
   Common cellular processes: Differentiation

Circuit 365: Ste12 Taf12
   Transcription regulation path:  Ste12 --> Taf12
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Ngg1 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 366: Ste12 Taf12
   Transcription regulation path:  Ste12 --> Taf12
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Ada2 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 367: Ste12 Met18
   Transcription regulation path:  Ste12 --> Swi5 --> Met18
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Med11 <-> Met18
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 368: Ste12 Ste3
   Transcription regulation path:  Ste12 --> Sum1 --> Ste3
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste5 <-> Akr1 <-> Ste3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Plasma membrane<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.000301
   Common cellular processes: Mating response, Signal transduction

Circuit 369: Ste12 Red1
   Transcription regulation path:  Ste12 --> Mss11 --> Rox1 --> Ume6 --> Red1
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Smt3 <-> Red1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.047972
   Common cellular processes: Differentiation

Circuit 370: Ste12 Rim11
   Transcription regulation path:  Ste12 --> Swi5 --> Rme1 --> Ime1 --> Rim11
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Rim11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 371: Ste12 Sto1
   Transcription regulation path:  Ste12 --> Hrt1 --> Sto1
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Cbc2 <-> Sto1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 372: Ste12 Lsm3
   Transcription regulation path:  Ste12 --> Swi5 --> Lsm3
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste11 <-> Lsm1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013234
   Common cellular processes: Mating response, Signal transduction

Circuit 373: Ste12 Dhh1
   Transcription regulation path:  Ste12 --> Dhh1
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Pop2 <-> Dhh1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 374: Ste12 Lsm6
   Transcription regulation path:  Ste12 --> Lsm6
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste11 <-> Lsm1 <-> Lsm6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response, Signal transduction

Circuit 375: Ste12 Smk1
   Transcription regulation path:  Ste12 --> Sum1 --> Smk1
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Qcr2 <-> Smk1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 376: Ste12 Dmc1
   Transcription regulation path:  Ste12 --> Mss11 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.041965
   Common cellular processes: Differentiation

Circuit 377: Ste12 Tfa2
   Transcription regulation path:  Ste12 --> Swi5 --> Rme1 --> Tfa2
   Protein-protein interaction path: Ste12 <-> Mcm1 <-> Srb4 <-> Gal11 <-> Tfa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 378: Ste12 Car1
   Transcription regulation path:  Ste12 --> Mss11 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ste12 <-> Dig1 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.041965
   Common cellular processes: Differentiation

Circuit 379: Ste12 Far1
   Transcription regulation path:  Ste12 --> Far1
   Protein-protein interaction path: Ste12 <-> Kss1 <-> Ste5 <-> Ste4 <-> Far1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Plasma membrane<=> Complex
   Circuit significance based on cellular process assessment: 0.000050
   Common cellular processes: Mating response

Circuit 380: Hap4 Nup42
   Transcription regulation path:  Hap4 --> Nup42
   Protein-protein interaction path: Hap4 <-> Iki1 <-> Nup116 <-> Kap104 <-> Nup42
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.003359
   Common cellular processes: Energy generation

Circuit 381: Abf1 Mek1
   Transcription regulation path:  Abf1 --> Ume6 --> Mek1
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Smd3 <-> Stb5 <-> Mek1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.015891
   Common cellular processes: Chromatin/chromosome structure

Circuit 382: Abf1 Prp4
   Transcription regulation path:  Abf1 --> Prp4
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Lsm8 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 383: Abf1 Prp4
   Transcription regulation path:  Abf1 --> Prp4
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Lsm7 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 384: Abf1 Prp4
   Transcription regulation path:  Abf1 --> Prp4
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Lsm3 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 385: Abf1 Prp4
   Transcription regulation path:  Abf1 --> Prp4
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Smd3 <-> Lsm8 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: Chromatin/chromosome structure, RNA processing/modification, RNA splicing

Circuit 386: Abf1 Prp4
   Transcription regulation path:  Abf1 --> Prp4
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Smd3 <-> Snu66 <-> Prp4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: Chromatin/chromosome structure, RNA processing/modification, RNA splicing

Circuit 387: Abf1 Tfa1
   Transcription regulation path:  Abf1 --> Tfa1
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Srb4 <-> Gal11 <-> Tfa1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 388: Abf1 Pdr1
   Transcription regulation path:  Abf1 --> Pdr1
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Srb4 <-> Ngg1 <-> Pdr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 389: Abf1 Mhr1
   Transcription regulation path:  Abf1 --> Mhr1
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Srb4 <-> Gal4 <-> Mhr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 390: Abf1 Nup170
   Transcription regulation path:  Abf1 --> Nup170
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Tps1 <-> Nup1 <-> Nup170
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.007471
   Common cellular processes: Chromatin/chromosome structure

Circuit 391: Abf1 Prp8
   Transcription regulation path:  Abf1 --> Prp8
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Lsm8 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 392: Abf1 Prp8
   Transcription regulation path:  Abf1 --> Prp8
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Lsm3 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 393: Abf1 Prp8
   Transcription regulation path:  Abf1 --> Prp8
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Msl1 <-> Snu114 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 394: Abf1 Prp8
   Transcription regulation path:  Abf1 --> Prp8
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Smd3 <-> Lsm8 <-> Prp8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: Chromatin/chromosome structure, RNA processing/modification, RNA splicing

Circuit 395: Abf1 Sin4
   Transcription regulation path:  Abf1 --> Pdr1 --> Sin4
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Srb4 <-> Gal11 <-> Sin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 396: Abf1 Hsh49
   Transcription regulation path:  Abf1 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 397: Abf1 Rpo21
   Transcription regulation path:  Abf1 --> Rpo21
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Srb4 <-> Gal11 <-> Rpo21
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 398: Abf1 Rad23
   Transcription regulation path:  Abf1 --> Rad23
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Rad7 <-> Rad4 <-> Rad23
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000050
   Common cellular processes: DNA repair

Circuit 399: Abf1 Spt8
   Transcription regulation path:  Abf1 --> Spt8
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Msl1 <-> Tra1 <-> Spt8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000903
   Common cellular processes: Chromatin/chromosome structure

Circuit 400: Abf1 Gts1
   Transcription regulation path:  Abf1 --> Ume6 --> Hsf1 --> Reb1 --> Gts1
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Srb4 <-> Yap6 <-> Gts1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 401: Abf1 Gcn5
   Transcription regulation path:  Abf1 --> Gcn5
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Msl1 <-> Tra1 <-> Gcn5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000903
   Common cellular processes: Chromatin/chromosome structure

Circuit 402: Abf1 Yng2
   Transcription regulation path:  Abf1 --> Yng2
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Msl1 <-> Tra1 <-> Yng2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000903
   Common cellular processes: Chromatin/chromosome structure

Circuit 403: Abf1 Htb1
   Transcription regulation path:  Abf1 --> Pho2 --> Htb1
   Protein-protein interaction path: Abf1 <-> Rad16 <-> Rad7 <-> Sir3 <-> Htb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002005
   Common cellular processes: Chromatin/chromosome structure

Circuit 404: Abf1 Dhh1
   Transcription regulation path:  Abf1 --> Dhh1
   Protein-protein interaction path: Abf1 <-> Ckb2 <-> Lsm4 <-> Lsm2 <-> Dhh1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification

Circuit 405: Cyc8 Hxt3
   Transcription regulation path:  Cyc8 --> Hxt3
   Protein-protein interaction path: Cyc8 <-> Mig1 <-> Snf1 <-> Std1 <-> Hxt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.000802
   Common cellular processes: Carbohydrate metabolism

Circuit 406: Tup1 Net1
   Transcription regulation path:  Tup1 --> Rox1 --> Yap6 --> Cin5 --> Net1
   Protein-protein interaction path: Tup1 <-> Hht1 <-> Sir4 <-> Sir2 <-> Net1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear transport factor
   Circuit significance based on cellular process assessment: 0.000200
   Common cellular processes: Chromatin/chromosome structure

Circuit 407: Tup1 Net1
   Transcription regulation path:  Tup1 --> Rox1 --> Yap6 --> Cin5 --> Net1
   Protein-protein interaction path: Tup1 <-> Hhf1 <-> Sir4 <-> Sir2 <-> Net1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear transport factor
   Circuit significance based on cellular process assessment: 0.000200
   Common cellular processes: Chromatin/chromosome structure

Circuit 408: Tup1 Smt3
   Transcription regulation path:  Tup1 --> Rox1 --> Yap6 --> Cin5 --> Smt3
   Protein-protein interaction path: Tup1 <-> Hht1 <-> Sir4 <-> Ris1 <-> Smt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004907
   Common cellular processes: Chromatin/chromosome structure

Circuit 409: Tup1 Smt3
   Transcription regulation path:  Tup1 --> Rox1 --> Yap6 --> Cin5 --> Smt3
   Protein-protein interaction path: Tup1 <-> Hhf1 <-> Sir4 <-> Ris1 <-> Smt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004907
   Common cellular processes: Chromatin/chromosome structure

Circuit 410: Tup1 Ste5
   Transcription regulation path:  Tup1 --> Ste5
   Protein-protein interaction path: Tup1 <-> Qri2 <-> Hsc82 <-> Ste11 <-> Ste5
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response
   Circuit significance based on results of knockout experiments: 0.0001
   Circuit potential targets: Ste2 down, Bar1 down, Ste6 down, Sst2 down.

Circuit 411: Tup1 Ste5
   Transcription regulation path:  Tup1 --> Ste5
   Protein-protein interaction path: Tup1 <-> Sko1 <-> Hog1 <-> Ste11 <-> Ste5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0001
   Circuit potential targets: Ste2 down, Bar1 down, Ste6 down, Sst2 down.

Circuit 412: Tup1 Ste4
   Transcription regulation path:  Tup1 --> Ste4
   Protein-protein interaction path: Tup1 <-> Matalpha2 <-> Nup84 <-> Mrp4 <-> Ste4
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response
   Circuit significance based on results of knockout experiments: 0.0115
   Circuit potential targets: Ste2 down, Ste6 down, Sst2 down.

Circuit 413: Tup1 Ste4
   Transcription regulation path:  Tup1 --> Ste4
   Protein-protein interaction path: Tup1 <-> Matalpha2 <-> Mec3 <-> Apg16 <-> Ste4
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response
   Circuit significance based on results of knockout experiments: 0.0115
   Circuit potential targets: Ste2 down, Ste6 down, Sst2 down.

Circuit 414: Tup1 Ste4
   Transcription regulation path:  Tup1 --> Ste4
   Protein-protein interaction path: Tup1 <-> Qri2 <-> Hsc82 <-> Ste11 <-> Ste4
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response
   Circuit significance based on results of knockout experiments: 0.0115
   Circuit potential targets: Ste2 down, Ste6 down, Sst2 down.

Circuit 415: Tup1 Ste4
   Transcription regulation path:  Tup1 --> Ste4
   Protein-protein interaction path: Tup1 <-> Sko1 <-> Hog1 <-> Ste11 <-> Ste4
   Circuit significance based on cellular process assessment: 0.006769
   Common cellular processes: Mating response, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0115
   Circuit potential targets: Ste2 down, Ste6 down, Sst2 down.

Circuit 416: Tup1 Std1
   Transcription regulation path:  Tup1 --> Rox1 --> Yap6 --> Cin5 --> Std1
   Protein-protein interaction path: Tup1 <-> Cyc8 <-> Mig1 <-> Snf1 <-> Std1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 417: Tup1 Dmc1
   Transcription regulation path:  Tup1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Tup1 <-> Hht1 <-> Sir4 <-> Ris1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003960
   Common cellular processes: Chromatin/chromosome structure

Circuit 418: Tup1 Dmc1
   Transcription regulation path:  Tup1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Tup1 <-> Hhf1 <-> Sir4 <-> Ris1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003960
   Common cellular processes: Chromatin/chromosome structure

Circuit 419: Tup1 Ume6
   Transcription regulation path:  Tup1 --> Rox1 --> Ume6
   Protein-protein interaction path: Tup1 <-> Matalpha2 <-> Mcm1 <-> Arg81 <-> Ume6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013234
   Common cellular processes: Mating response

Circuit 420: Tup1 Ume6
   Transcription regulation path:  Tup1 --> Rox1 --> Ume6
   Protein-protein interaction path: Tup1 <-> Matalpha2 <-> Mcm1 <-> Arg80 <-> Ume6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013234
   Common cellular processes: Mating response

Circuit 421: Tup1 Rim11
   Transcription regulation path:  Tup1 --> Ime1 --> Rim11
   Protein-protein interaction path: Tup1 <-> Matalpha2 <-> Nup84 <-> Nup57 <-> Rim11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002958
   Common cellular processes: Meiosis

Circuit 422: Tup1 Ime1
   Transcription regulation path:  Tup1 --> Ime1
   Protein-protein interaction path: Tup1 <-> Hht1 <-> Hta1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 423: Tup1 Ime1
   Transcription regulation path:  Tup1 --> Ime1
   Protein-protein interaction path: Tup1 <-> Hhf1 <-> Hta1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 424: Tup1 Ime1
   Transcription regulation path:  Tup1 --> Ime1
   Protein-protein interaction path: Tup1 <-> Matalpha2 <-> Mcm1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 425: Cbf1 Sen1
   Transcription regulation path:  Cbf1 --> Reb1 --> Gts1 --> Sen1
   Protein-protein interaction path: Cbf1 <-> Mcm21 <-> Smb1 <-> Smd3 <-> Sen1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003960
   Common cellular processes: Chromatin/chromosome structure

Circuit 426: Cbf1 Cln2
   Transcription regulation path:  Cbf1 --> Reb1 --> Swi5 --> Rme1 --> Cln2
   Protein-protein interaction path: Cbf1 <-> Met4 <-> Met30 <-> Cdc53 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.002003
   Common cellular processes: Amino-acid metabolism

Circuit 427: Cbf1 Cln2
   Transcription regulation path:  Cbf1 --> Reb1 --> Swi5 --> Ash1 --> Cln2
   Protein-protein interaction path: Cbf1 <-> Met4 <-> Met30 <-> Cdc53 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.002003
   Common cellular processes: Amino-acid metabolism

Circuit 428: Cbf1 Cln2
   Transcription regulation path:  Cbf1 --> Reb1 --> Sin3 --> Rme1 --> Cln2
   Protein-protein interaction path: Cbf1 <-> Met4 <-> Met30 <-> Cdc53 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.002003
   Common cellular processes: Amino-acid metabolism

Circuit 429: Cbf1 Hrr25
   Transcription regulation path:  Cbf1 --> Reb1 --> Hrr25
   Protein-protein interaction path: Cbf1 <-> Mcm21 <-> Srp1 <-> Rad51 <-> Hrr25
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.015891
   Common cellular processes: Chromatin/chromosome structure

Circuit 430: Cbf1 Grr1
   Transcription regulation path:  Cbf1 --> Reb1 --> Grr1
   Protein-protein interaction path: Cbf1 <-> Met4 <-> Met30 <-> Cdc53 <-> Grr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000000
   Common cellular processes: Amino-acid metabolism

Circuit 431: Cbf1 Grr1
   Transcription regulation path:  Cbf1 --> Reb1 --> Grr1
   Protein-protein interaction path: Cbf1 <-> Met4 <-> Met30 <-> Skp1 <-> Grr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000000
   Common cellular processes: Amino-acid metabolism

Circuit 432: Hrt1 Pop7
   Transcription regulation path:  Hrt1 --> Srd1 --> Pop7
   Protein-protein interaction path: Hrt1 <-> Cdc4 <-> Cdc34 <-> Rpb9 <-> Pop7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.047373
   Common cellular processes: RNA processing/modification

Circuit 433: Hrt1 Pop7
   Transcription regulation path:  Hrt1 --> Srd1 --> Pop7
   Protein-protein interaction path: Hrt1 <-> Cdc53 <-> Cdc34 <-> Rpb9 <-> Pop7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.047373
   Common cellular processes: Protein degradation, RNA processing/modification

Circuit 434: Hrt1 Pop7
   Transcription regulation path:  Hrt1 --> Srd1 --> Pop7
   Protein-protein interaction path: Hrt1 <-> Grr1 <-> Cdc34 <-> Rpb9 <-> Pop7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.047373
   Common cellular processes: Protein degradation, RNA processing/modification

Circuit 435: Hrt1 Pop7
   Transcription regulation path:  Hrt1 --> Srd1 --> Pop7
   Protein-protein interaction path: Hrt1 <-> Skp1 <-> Cdc34 <-> Rpb9 <-> Pop7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.047373
   Common cellular processes: Protein degradation, RNA processing/modification

Circuit 436: Gln3 Nnf1
   Transcription regulation path:  Gln3 --> Gcn4 --> Nnf1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Spc19 <-> Smc1 <-> Nnf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002356
   Common cellular processes: Mitosis

Circuit 437: Gln3 Nnf1
   Transcription regulation path:  Gln3 --> Gcn4 --> Nnf1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Spc19 <-> Nuf2 <-> Nnf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Centrosome/spindle pole body, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002356
   Common cellular processes: Mitosis

Circuit 438: Gln3 Nnf1
   Transcription regulation path:  Gln3 --> Gcn4 --> Nnf1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Spc19 <-> Tid3 <-> Nnf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Centrosome/spindle pole body, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002356
   Common cellular processes: Mitosis

Circuit 439: Gln3 Pom152
   Transcription regulation path:  Gln3 --> Uga3 --> Pom152
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup57 <-> Nic96 <-> Pom152
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 440: Gln3 Pom152
   Transcription regulation path:  Gln3 --> Uga3 --> Pom152
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup49 <-> Nic96 <-> Pom152
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 441: Gln3 Pom152
   Transcription regulation path:  Gln3 --> Uga3 --> Pom152
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup100 <-> Nup188 <-> Pom152
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 442: Gln3 Met4
   Transcription regulation path:  Gln3 --> Gcn4 --> Met4
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Mcm21 <-> Cbf1 <-> Met4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.005414
   Common cellular processes: Amino-acid metabolism

Circuit 443: Gln3 Hrb1
   Transcription regulation path:  Gln3 --> Gcn4 --> Hrb1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Gsp1 <-> Mtr10 <-> Hrb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 444: Gln3 Hrb1
   Transcription regulation path:  Gln3 --> Gcn4 --> Hrb1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup57 <-> Mtr10 <-> Hrb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 445: Gln3 Hrb1
   Transcription regulation path:  Gln3 --> Gcn4 --> Hrb1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup116 <-> Mtr10 <-> Hrb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 446: Gln3 Hrb1
   Transcription regulation path:  Gln3 --> Gcn4 --> Hrb1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup1 <-> Mtr10 <-> Hrb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 447: Gln3 Sen2
   Transcription regulation path:  Gln3 --> Gcn4 --> Stb1 --> Ndd1 --> Sen2
   Protein-protein interaction path: Gln3 <-> Gts1 <-> Lys14 <-> Sen2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 448: Gln3 Mhp1
   Transcription regulation path:  Gln3 --> Gcn4 --> Yap5 --> Mhp1
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Bcy1 <-> Glc7 <-> Mhp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.022104
   Common cellular processes: Cell stress

Circuit 449: Gln3 Dbf20
   Transcription regulation path:  Gln3 --> Gcn4 --> Dbf20
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Ntf2 <-> Nup145 <-> Dbf20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 450: Gln3 Dbf20
   Transcription regulation path:  Gln3 --> Gcn4 --> Dbf20
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup57 <-> Nup145 <-> Dbf20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 451: Gln3 Dbf20
   Transcription regulation path:  Gln3 --> Gcn4 --> Dbf20
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup49 <-> Nup145 <-> Dbf20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 452: Gln3 Dbf20
   Transcription regulation path:  Gln3 --> Gcn4 --> Dbf20
   Protein-protein interaction path: Gln3 <-> Srp1 <-> Nup100 <-> Nup145 <-> Dbf20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 453: Gln3 Gdh1
   Transcription regulation path:  Gln3 --> Gdh1
   Protein-protein interaction path: Gln3 <-> Ste50 <-> Ste11 <-> Lsm1 <-> Gdh1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic<=> Cytoplasmic<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.003911
   Common cellular processes: Differentiation

Circuit 454: Yap1 Trf4
   Transcription regulation path:  Yap1 --> Trf4
   Protein-protein interaction path: Yap1 <-> Kap95 <-> Spc29 <-> Smc2 <-> Trf4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.007471
   Common cellular processes: Chromatin/chromosome structure, Mitosis

Circuit 455: Yap1 Hop1
   Transcription regulation path:  Yap1 --> Rox1 --> Ume6 --> Hop1
   Protein-protein interaction path: Yap1 <-> Nup116 <-> Smt3 <-> Red1 <-> Hop1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008771
   Common cellular processes: Meiosis

Circuit 456: Yap1 Gac1
   Transcription regulation path:  Yap1 --> Yap6 --> Gac1
   Protein-protein interaction path: Yap1 <-> Kap95 <-> Bcy1 <-> Glc7 <-> Gac1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000050
   Common cellular processes: Cell stress

Circuit 457: Yap1 Zip1
   Transcription regulation path:  Yap1 --> Rox1 --> Ume6 --> Zip1
   Protein-protein interaction path: Yap1 <-> Nup116 <-> Jnm1 <-> Nuf2 <-> Zip1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Centrosome/spindle pole body, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.042604
   Common cellular processes: Meiosis, Mitosis

Circuit 458: Ace2 Tif5
   Transcription regulation path:  Ace2 --> Yap1 --> Tif5
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 459: Ace2 Tif5
   Transcription regulation path:  Ace2 --> Yap1 --> Tif5
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 460: Ace2 Tif5
   Transcription regulation path:  Ace2 --> Yap1 --> Tif5
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 461: Ace2 Tif5
   Transcription regulation path:  Ace2 --> Yap1 --> Tif5
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 462: Ace2 Tif5
   Transcription regulation path:  Ace2 --> Yap1 --> Tif5
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 463: Ace2 Tif5
   Transcription regulation path:  Ace2 --> Yap1 --> Tif5
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Srp1 <-> Tif5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 464: Ace2 Rpn1
   Transcription regulation path:  Ace2 --> Yap1 --> Rpn4 --> Rpn1
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Spt15 <-> Rpt6 <-> Rpn1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Endoplasmatic reticulum, Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 465: Ace2 Rpn1
   Transcription regulation path:  Ace2 --> Yap1 --> Rpn4 --> Rpn1
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Gal4 <-> Rpt6 <-> Rpn1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Endoplasmatic reticulum, Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 466: Ace2 Gac1
   Transcription regulation path:  Ace2 --> Yap1 --> Yap6 --> Gac1
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Bcy1 <-> Glc7 <-> Gac1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.002456
   Common cellular processes: Cell stress

Circuit 467: Ace2 Hxt3
   Transcription regulation path:  Ace2 --> Yap1 --> Yap6 --> Cin5 --> Hxt3
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Spt15 <-> Std1 <-> Hxt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 468: Ace2 Ctt1
   Transcription regulation path:  Ace2 --> Yap1 --> Ctt1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Srp1 <-> Ctt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 469: Ace2 Ctt1
   Transcription regulation path:  Ace2 --> Yap1 --> Ctt1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Srp1 <-> Ctt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 470: Ace2 Ctt1
   Transcription regulation path:  Ace2 --> Yap1 --> Ctt1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Srp1 <-> Ctt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 471: Ace2 Ctt1
   Transcription regulation path:  Ace2 --> Yap1 --> Ctt1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Srp1 <-> Ctt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 472: Ace2 Ctt1
   Transcription regulation path:  Ace2 --> Yap1 --> Ctt1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Srp1 <-> Ctt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 473: Ace2 Ctt1
   Transcription regulation path:  Ace2 --> Yap1 --> Ctt1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Srp1 <-> Ctt1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 474: Ace2 Gdh3
   Transcription regulation path:  Ace2 --> Gdh3
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 475: Ace2 Gdh3
   Transcription regulation path:  Ace2 --> Gdh3
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 476: Ace2 Gdh3
   Transcription regulation path:  Ace2 --> Gdh3
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 477: Ace2 Gdh3
   Transcription regulation path:  Ace2 --> Gdh3
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 478: Ace2 Gdh3
   Transcription regulation path:  Ace2 --> Gdh3
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 479: Ace2 Gdh3
   Transcription regulation path:  Ace2 --> Gdh3
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 480: Ace2 Tsa2
   Transcription regulation path:  Ace2 --> Yap1 --> Tsa2
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Srp1 <-> Tsa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 481: Ace2 Tsa2
   Transcription regulation path:  Ace2 --> Yap1 --> Tsa2
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Srp1 <-> Tsa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 482: Ace2 Tsa2
   Transcription regulation path:  Ace2 --> Yap1 --> Tsa2
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Srp1 <-> Tsa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 483: Ace2 Tsa2
   Transcription regulation path:  Ace2 --> Yap1 --> Tsa2
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Srp1 <-> Tsa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 484: Ace2 Tsa2
   Transcription regulation path:  Ace2 --> Yap1 --> Tsa2
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Srp1 <-> Tsa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 485: Ace2 Tsa2
   Transcription regulation path:  Ace2 --> Yap1 --> Tsa2
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Srp1 <-> Tsa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 486: Ace2 Dmc1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 487: Ace2 Dmc1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 488: Ace2 Dmc1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 489: Ace2 Dmc1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 490: Ace2 Dmc1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 491: Ace2 Dmc1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Srp1 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 492: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 493: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 494: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 495: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 496: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup159 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 497: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 498: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 499: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup145 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 500: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 501: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 502: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 503: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 504: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Srp1 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 505: Ace2 Car1
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Ume6 --> Car1
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Kap95 <-> Car1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013821
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 506: Ace2 Tfa2
   Transcription regulation path:  Ace2 --> Rme1 --> Tfa2
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Gal4 <-> Gal11 <-> Tfa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 507: Ace2 Tfa2
   Transcription regulation path:  Ace2 --> Rme1 --> Tfa2
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Med6 <-> Gal11 <-> Tfa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: Pol II transcription

Circuit 508: Ace2 Hem13
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Hem13
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup1 <-> Srp1 <-> Hem13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 509: Ace2 Hem13
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Hem13
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Gsp1 <-> Srp1 <-> Hem13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 510: Ace2 Hem13
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Hem13
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup57 <-> Srp1 <-> Hem13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 511: Ace2 Hem13
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Hem13
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup49 <-> Srp1 <-> Hem13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 512: Ace2 Hem13
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Hem13
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup100 <-> Srp1 <-> Hem13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 513: Ace2 Hem13
   Transcription regulation path:  Ace2 --> Yap1 --> Rox1 --> Hem13
   Protein-protein interaction path: Ace2 <-> Crm1 <-> Nup116 <-> Srp1 <-> Hem13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 514: Ace2 Std1
   Transcription regulation path:  Ace2 --> Yap1 --> Yap6 --> Cin5 --> Std1
   Protein-protein interaction path: Ace2 <-> Sua7 <-> Spt15 <-> Std1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 515: Dal82 Taf3
   Transcription regulation path:  Dal82 --> Taf3
   Protein-protein interaction path: Dal82 <-> Std1 <-> Pop2 <-> Srb4 <-> Taf3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 516: Bas1 Siz1
   Transcription regulation path:  Bas1 --> Siz1
   Protein-protein interaction path: Bas1 <-> Lsm3 <-> Lsm4 <-> Prp11 <-> Siz1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 517: Sin3 Mer1
   Transcription regulation path:  Sin3 --> Rme1 --> Ime1 --> Mer1
   Protein-protein interaction path: Sin3 <-> Ume6 <-> Rim11 <-> Srb4 <-> Mer1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Meiosis

Circuit 518: Sin3 Ime2
   Transcription regulation path:  Sin3 --> Rme1 --> Ime1 --> Ime2
   Protein-protein interaction path: Sin3 <-> Lsm4 <-> Smd2 <-> Smx3 <-> Ime2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 519: Cad1 Hta1
   Transcription regulation path:  Cad1 --> Hir1 --> Hta1
   Protein-protein interaction path: Cad1 <-> Nup116 <-> Yap1 <-> Srb4 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 520: Swi4 Zpr1
   Transcription regulation path:  Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.012230
   Common cellular processes: Cell cycle control

Circuit 521: Swi4 Zpr1
   Transcription regulation path:  Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Far1 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.012230
   Common cellular processes: Cell cycle control

Circuit 522: Swi4 Zpr1
   Transcription regulation path:  Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc53 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.012230
   Common cellular processes: Cell cycle control

Circuit 523: Swi4 Zpr1
   Transcription regulation path:  Swi4 --> Sok2 --> Msn4 --> Zpr1
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Cln1 <-> Zpr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.012230
   Common cellular processes: Cell cycle control

Circuit 524: Swi4 Fks1
   Transcription regulation path:  Swi4 --> Fks1
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Mkk1 <-> Pkc1 <-> Fks1
   Circuit significance based on cellular process assessment: 0.014089
   Common cellular processes: Cell stress, Cell wall maintenance, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0003
   Circuit potential targets: Sed1 up, Crh1 up, Cis3 up, Cwp1 up, Tos11 up, Svs1 up, Sim1 up, Cwp2 up, Uth1 up, Srl1 up.

Circuit 525: Swi4 Lsm3
   Transcription regulation path:  Swi4 --> Lsm3
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Smd3 <-> Smb1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 526: Swi4 Lsm3
   Transcription regulation path:  Swi4 --> Lsm3
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Smd3 <-> Lsm8 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 527: Swi4 Htb1
   Transcription regulation path:  Swi4 --> Htb1
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Nap1 <-> Hta1 <-> Htb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Complex<=> Complex<=> Nuclear
   Circuit significance based on cellular process assessment: 0.007471
   Common cellular processes: Chromatin/chromosome structure

Circuit 528: Swi4 Rsr1
   Transcription regulation path:  Swi4 --> Rsr1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Ste20 <-> Cdc24 <-> Rsr1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoskeletal<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.008022
   Common cellular processes: Cell polarity

Circuit 529: Swi4 Rck1
   Transcription regulation path:  Swi4 --> Sok2 --> Rck1
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Ptp2 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.002607
   Common cellular processes: Signal transduction

Circuit 530: Swi4 Rck1
   Transcription regulation path:  Swi4 --> Sok2 --> Rck1
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Ptp3 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.002607
   Common cellular processes: Signal transduction

Circuit 531: Swi4 Hsh49
   Transcription regulation path:  Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Swi4 <-> Slt2 <-> Smd3 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 532: Swi4 Swe1
   Transcription regulation path:  Swi4 --> Swe1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Far1 <-> Cdc24 <-> Swe1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Bud neck, Nuclear
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Cell cycle control

Circuit 533: Swi4 Swe1
   Transcription regulation path:  Swi4 --> Swe1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc53 <-> Met30 <-> Swe1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Cell cycle control

Circuit 534: Swi4 Bbp1
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Ash1 --> Bbp1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc28 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 535: Swi4 Bbp1
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Ash1 --> Bbp1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Far1 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 536: Swi4 Bbp1
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Ash1 --> Bbp1
   Protein-protein interaction path: Swi4 <-> Cln2 <-> Cdc53 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 537: Swi4 Bbp1
   Transcription regulation path:  Swi4 --> Ndd1 --> Swi5 --> Ash1 --> Bbp1
   Protein-protein interaction path: Swi4 <-> Clb2 <-> Cdc28 <-> Cln1 <-> Bbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004707
   Common cellular processes: Cell cycle control

Circuit 538: Mig1 Rpl16a
   Transcription regulation path:  Mig1 --> Gal4 --> Rpl16a
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup57 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022358
   Common cellular processes: Carbohydrate metabolism, Nuclear-cytoplasmic transport

Circuit 539: Mig1 Rpl16a
   Transcription regulation path:  Mig1 --> Gal4 --> Rpl16a
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup1 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022358
   Common cellular processes: Carbohydrate metabolism, Nuclear-cytoplasmic transport

Circuit 540: Mig1 Rpl16a
   Transcription regulation path:  Mig1 --> Gal4 --> Rpl16a
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup100 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022358
   Common cellular processes: Carbohydrate metabolism, Nuclear-cytoplasmic transport

Circuit 541: Mig1 Rpl16a
   Transcription regulation path:  Mig1 --> Gal4 --> Rpl16a
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup116 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.022358
   Common cellular processes: Carbohydrate metabolism, Nuclear-cytoplasmic transport

Circuit 542: Mig1 Fbp1
   Transcription regulation path:  Mig1 --> Fbp1
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup42 <-> Srp1 <-> Fbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.006919
   Common cellular processes: Carbohydrate metabolism

Circuit 543: Mig1 Fbp1
   Transcription regulation path:  Mig1 --> Fbp1
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup42 <-> Kap95 <-> Fbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.006919
   Common cellular processes: Carbohydrate metabolism

Circuit 544: Mig1 Fbp1
   Transcription regulation path:  Mig1 --> Fbp1
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Hmo1 <-> Srp1 <-> Fbp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.006919
   Common cellular processes: Carbohydrate metabolism

Circuit 545: Mig1 Sec31
   Transcription regulation path:  Mig1 --> Gal4 --> Mth1 --> Sec31
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup145 <-> Sec13 <-> Sec31
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Complex<=> Cytoplasmic, Other vesicles of the secretory/endocytic pathways
   Circuit significance based on cellular process assessment: 0.009674
   Common cellular processes: Carbohydrate metabolism

Circuit 546: Mig1 Htb1
   Transcription regulation path:  Mig1 --> Gal4 --> Hir2 --> Htb1
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Hir2 <-> Snf5 <-> Htb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 547: Mig1 Dal80
   Transcription regulation path:  Mig1 --> Swi5 --> Gat1 --> Dal80
   Protein-protein interaction path: Mig1 <-> Cyc8 <-> Tup1 <-> Hda1 <-> Dal80
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 548: Mig1 Ckb2
   Transcription regulation path:  Mig1 --> Gal4 --> Ckb2
   Protein-protein interaction path: Mig1 <-> Mud2 <-> Prp11 <-> Lsm4 <-> Ckb2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003559
   Common cellular processes: RNA splicing

Circuit 549: Mig1 Qcr2
   Transcription regulation path:  Mig1 --> Hap4 --> Qcr2
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup42 <-> Srp1 <-> Qcr2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Complex
   Circuit significance based on cellular process assessment: 0.003660
   Common cellular processes: Energy generation

Circuit 550: Mig1 Prp3
   Transcription regulation path:  Mig1 --> Hap4 --> Prp3
   Protein-protein interaction path: Mig1 <-> Cus1 <-> Brr2 <-> Lsm8 <-> Prp3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 551: Mig1 Prp3
   Transcription regulation path:  Mig1 --> Hap4 --> Prp3
   Protein-protein interaction path: Mig1 <-> Cus1 <-> Brr2 <-> Lsm3 <-> Prp3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 552: Mig1 Prp3
   Transcription regulation path:  Mig1 --> Hap4 --> Prp3
   Protein-protein interaction path: Mig1 <-> Cus1 <-> Hsh49 <-> Lsm8 <-> Prp3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 553: Mig1 Tps3
   Transcription regulation path:  Mig1 --> Swi5 --> Tps3
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup1 <-> Tps1 <-> Tps3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.005514
   Common cellular processes: Carbohydrate metabolism, Cell stress

Circuit 554: Mig1 Dam1
   Transcription regulation path:  Mig1 --> Gal4 --> Dam1
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Nup57 <-> Mcm16 <-> Dam1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.022358
   Common cellular processes: Carbohydrate metabolism

Circuit 555: Mig1 Hap4
   Transcription regulation path:  Mig1 --> Hap4
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Std1 <-> Iki1 <-> Hap4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 556: Mig1 Hta1
   Transcription regulation path:  Mig1 --> Gal4 --> Hir2 --> Hta1
   Protein-protein interaction path: Mig1 <-> Cyc8 <-> Tup1 <-> Hht1 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 557: Mig1 Hta1
   Transcription regulation path:  Mig1 --> Gal4 --> Hir2 --> Hta1
   Protein-protein interaction path: Mig1 <-> Cyc8 <-> Tup1 <-> Hhf1 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 558: Mig1 Taf12
   Transcription regulation path:  Mig1 --> Swi5 --> Rme1 --> Taf12
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Std1 <-> Spt15 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 559: Mig1 Taf12
   Transcription regulation path:  Mig1 --> Swi5 --> Rme1 --> Taf12
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Std1 <-> Taf9 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 560: Mig1 Gdh3
   Transcription regulation path:  Mig1 --> Swi5 --> Gdh3
   Protein-protein interaction path: Mig1 <-> Msn5 <-> Gsp1 <-> Srp1 <-> Gdh3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.004913
   Common cellular processes: Cell cycle control

Circuit 561: Mig1 Gal4
   Transcription regulation path:  Mig1 --> Gal4
   Protein-protein interaction path: Mig1 <-> Snf1 <-> Std1 <-> Spt15 <-> Gal4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Carbohydrate metabolism, Pol II transcription

Circuit 562: Mig1 Gal4
   Transcription regulation path:  Mig1 --> Gal4
   Protein-protein interaction path: Mig1 <-> Cus1 <-> Rpt5 <-> Rpt4 <-> Gal4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Endoplasmatic reticulum, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 563: Met4 Met17
   Transcription regulation path:  Met4 --> Met17
   Protein-protein interaction path: Met4 <-> Cbf1 <-> Mcm21 <-> Srp1 <-> Met17
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.009677
   Common cellular processes: Amino-acid metabolism

Circuit 564: Spt16 Gin4
   Transcription regulation path:  Spt16 --> Swi6 --> Gin4
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Yrb1 <-> Nap1 <-> Gin4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 565: Spt16 Swi3
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Swi3
   Protein-protein interaction path: Spt16 <-> Pol1 <-> Pri1 <-> Rif2 <-> Swi3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001353
   Common cellular processes: DNA synthesis

Circuit 566: Spt16 Ded1
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Ded1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Yrb1 <-> Srm1 <-> Ded1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011929
   Common cellular processes: RNA processing/modification

Circuit 567: Spt16 Rad53
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Cup9 --> Rad53
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm4 <-> Stn1 <-> Rad53
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.018828
   Common cellular processes: RNA processing/modification

Circuit 568: Spt16 Rad53
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Cup9 --> Rad53
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm5 <-> Fob1 <-> Rad53
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear transport factor
   Circuit significance based on cellular process assessment: 0.018828
   Common cellular processes: RNA processing/modification

Circuit 569: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 570: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm4 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 571: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm5 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 572: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Mtr3 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 573: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm7 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 574: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm6 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 575: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm3 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 576: Spt16 Pcf11
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Msn4 --> Pcf11
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Dcp1 <-> Lsm8 <-> Pcf11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001502
   Common cellular processes: RNA processing/modification

Circuit 577: Spt16 Cla4
   Transcription regulation path:  Spt16 --> Swi6 --> Cla4
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Bem3 <-> Cla4
   Circuit significance based on cellular process assessment: 0.005364
   Common cellular processes: Cell polarity
   Circuit significance based on results of knockout experiments: 0.0263
   Circuit potential targets: Cln2 up.

Circuit 578: Spt16 Cla4
   Transcription regulation path:  Spt16 --> Swi4 --> Cla4
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Bem3 <-> Cla4
   Circuit significance based on cellular process assessment: 0.005364
   Common cellular processes: Cell polarity
   Circuit significance based on results of knockout experiments: 0.0263
   Circuit potential targets: Cln2 up.

Circuit 579: Spt16 Hpr5
   Transcription regulation path:  Spt16 --> Swi6 --> Hpr5
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Snu114 <-> Msl1 <-> Hpr5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Complex<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006968
   Common cellular processes: RNA processing/modification

Circuit 580: Spt16 Mcm16
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Pho2 --> Mcm16
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Prp24 <-> Mcm16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.018828
   Common cellular processes: RNA processing/modification

Circuit 581: Spt16 Mcm16
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Pho2 --> Mcm16
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm5 <-> Prp24 <-> Mcm16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.018828
   Common cellular processes: RNA processing/modification

Circuit 582: Spt16 Mcm16
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Pho2 --> Mcm16
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm7 <-> Prp24 <-> Mcm16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.018828
   Common cellular processes: RNA processing/modification

Circuit 583: Spt16 Mcm16
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Pho2 --> Mcm16
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm6 <-> Prp24 <-> Mcm16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.018828
   Common cellular processes: RNA processing/modification

Circuit 584: Spt16 Mcm16
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Pho2 --> Mcm16
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm3 <-> Prp24 <-> Mcm16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.018828
   Common cellular processes: RNA processing/modification

Circuit 585: Spt16 Ipi2
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Ipi2
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Snu114 <-> Msl1 <-> Ipi2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Complex<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011929
   Common cellular processes: RNA processing/modification

Circuit 586: Spt16 Ste7
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Ste7
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Ste11 <-> Kss1 <-> Ste7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.002807
   Common cellular processes: Mating response

Circuit 587: Spt16 Ste7
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Ste7
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Ste11 <-> Fus3 <-> Ste7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.002807
   Common cellular processes: Mating response

Circuit 588: Spt16 Ste7
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Ste7
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Ste11 <-> Ste5 <-> Ste7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Cytoplasmic, Plasma membrane
   Circuit significance based on cellular process assessment: 0.002807
   Common cellular processes: Mating response

Circuit 589: Spt16 Pse1
   Transcription regulation path:  Spt16 --> Swi4 --> Pse1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Yrb1 <-> Gsp1 <-> Pse1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 590: Spt16 Yox1
   Transcription regulation path:  Spt16 --> Swi6 --> Yox1
   Protein-protein interaction path: Spt16 <-> Pol1 <-> Pri1 <-> Rif2 <-> Yox1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003359
   Common cellular processes: DNA synthesis

Circuit 591: Spt16 Yox1
   Transcription regulation path:  Spt16 --> Swi4 --> Yox1
   Protein-protein interaction path: Spt16 <-> Pol1 <-> Pri1 <-> Rif2 <-> Yox1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003359
   Common cellular processes: DNA synthesis

Circuit 592: Spt16 Dbf2
   Transcription regulation path:  Spt16 --> Swi6 --> Ndd1 --> Dbf2
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Dhh1 <-> Dbf2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.011929
   Common cellular processes: RNA processing/modification

Circuit 593: Spt16 Dbf2
   Transcription regulation path:  Spt16 --> Swi4 --> Ndd1 --> Dbf2
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Dhh1 <-> Dbf2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.011929
   Common cellular processes: RNA processing/modification

Circuit 594: Spt16 Top1
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Ume6 --> Top1
   Protein-protein interaction path: Spt16 <-> Pol1 <-> Pri1 <-> Rif2 <-> Top1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.006410
   Common cellular processes: DNA synthesis

Circuit 595: Spt16 Srp1
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Srp1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Yrb1 <-> Gsp1 <-> Srp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.012230
   Common cellular processes: Cell cycle control

Circuit 596: Spt16 Rad27
   Transcription regulation path:  Spt16 --> Swi6 --> Rad27
   Protein-protein interaction path: Spt16 <-> Pol1 <-> Pri1 <-> Rif2 <-> Rad27
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000150
   Common cellular processes: DNA synthesis

Circuit 597: Spt16 Rck1
   Transcription regulation path:  Spt16 --> Swi4 --> Sok2 --> Rck1
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Ste11 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.010275
   Common cellular processes: Signal transduction

Circuit 598: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm2 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 599: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm4 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 600: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm5 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 601: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Mtr3 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 602: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm7 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 603: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm6 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 604: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Lsm3 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 605: Spt16 Hsh49
   Transcription regulation path:  Spt16 --> Swi4 --> Pdr1 --> Hsh49
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Dcp1 <-> Lsm8 <-> Hsh49
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: RNA processing/modification

Circuit 606: Spt16 Nup57
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Nup57
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Yrb1 <-> Crm1 <-> Nup57
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 607: Spt16 Rad51
   Transcription regulation path:  Spt16 --> Swi6 --> Rad51
   Protein-protein interaction path: Spt16 <-> Lsm1 <-> Dcp1 <-> Hrr25 <-> Rad51
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.047373
   Common cellular processes: DNA repair, RNA processing/modification, RNA turnover

Circuit 608: Spt16 Rpc40
   Transcription regulation path:  Spt16 --> Swi6 --> Abf1 --> Rpc40
   Protein-protein interaction path: Spt16 <-> Pol1 <-> Pri1 <-> Rif2 <-> Rpc40
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001353
   Common cellular processes: DNA synthesis

Circuit 609: Rgt1 Taf3
   Transcription regulation path:  Rgt1 --> Mth1 --> Taf3
   Protein-protein interaction path: Rgt1 <-> Std1 <-> Pop2 <-> Srb4 <-> Taf3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 610: Spt4 Hta1
   Transcription regulation path:  Spt4 --> Hta1
   Protein-protein interaction path: Spt4 <-> Hir1 <-> Snf5 <-> Htb1 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Chromatin/chromosome structure, Pol II transcription

Circuit 611: Spt21 Hta1
   Transcription regulation path:  Spt21 --> Hta1
   Protein-protein interaction path: Spt21 <-> Rad53 <-> Asf1 <-> Hht1 <-> Hta1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.007471
   Common cellular processes: Chromatin/chromosome structure

Circuit 612: Spt21 Hhf1
   Transcription regulation path:  Spt21 --> Hhf1
   Protein-protein interaction path: Spt21 <-> Rad53 <-> Asf1 <-> Hht1 <-> Hhf1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.007471
   Common cellular processes: Chromatin/chromosome structure

Circuit 613: Phd1 Met17
   Transcription regulation path:  Phd1 --> Zms1 --> Leu3 --> Met4 --> Met17
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Met17
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.040238
   Common cellular processes: Amino-acid metabolism

Circuit 614: Phd1 Ste12
   Transcription regulation path:  Phd1 --> Ste12
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Dig1 <-> Ste12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.003911
   Common cellular processes: Differentiation

Circuit 615: Phd1 Far1
   Transcription regulation path:  Phd1 --> Ste12 --> Far1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Ris1 <-> Lsm2 <-> Far1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013234
   Common cellular processes: Mating response

Circuit 616: Phd1 Dib1
   Transcription regulation path:  Phd1 --> Ste12 --> Mss11 --> Dib1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Ubc9 <-> Prp6 <-> Dib1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.042705
   Common cellular processes: Differentiation

Circuit 617: Phd1 Myo4
   Transcription regulation path:  Phd1 --> Ste12 --> Myo4
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> She2 <-> Myo4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 618: Phd1 Mek1
   Transcription regulation path:  Phd1 --> Msn4 --> Rox1 --> Ume6 --> Mek1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Red1 <-> Glc7 <-> Mek1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001402
   Common cellular processes: Meiosis

Circuit 619: Phd1 Mek1
   Transcription regulation path:  Phd1 --> Yap1 --> Rox1 --> Ume6 --> Mek1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Red1 <-> Glc7 <-> Mek1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001402
   Common cellular processes: Meiosis

Circuit 620: Phd1 Rim11
   Transcription regulation path:  Phd1 --> Ime1 --> Rim11
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Nup116 <-> Ume6 <-> Rim11
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002958
   Common cellular processes: Meiosis

Circuit 621: Phd1 Fus3
   Transcription regulation path:  Phd1 --> Ste12 --> Fus3
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Dig1 <-> Fus3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 622: Phd1 Spo12
   Transcription regulation path:  Phd1 --> Ste12 --> Spo12
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Mcm21 <-> Spo12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 623: Phd1 Spo12
   Transcription regulation path:  Phd1 --> Hrt1 --> Spo12
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Mcm21 <-> Spo12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017044
   Common cellular processes: Differentiation

Circuit 624: Phd1 Rad16
   Transcription regulation path:  Phd1 --> Rad16
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Hpr5 <-> Msl1 <-> Rad16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.016947
   Common cellular processes: DNA repair

Circuit 625: Phd1 Nmd5
   Transcription regulation path:  Phd1 --> Msn2 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Nup1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.025839
   Common cellular processes: Cell stress

Circuit 626: Phd1 Nmd5
   Transcription regulation path:  Phd1 --> Cup9 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Nup1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.025839
   Common cellular processes: Cell stress

Circuit 627: Phd1 Nmd5
   Transcription regulation path:  Phd1 --> Yap1 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Nup1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear
   Circuit significance based on cellular process assessment: 0.025839
   Common cellular processes: Cell stress

Circuit 628: Phd1 Ime1
   Transcription regulation path:  Phd1 --> Ime1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Nup116 <-> Ume6 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.016947
   Common cellular processes: Meiosis

Circuit 629: Phd1 Sir3
   Transcription regulation path:  Phd1 --> Yap1 --> Sir3
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Ris1 <-> Sir4 <-> Sir3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.015891
   Common cellular processes: Chromatin/chromosome structure

Circuit 630: Phd1 Mhp1
   Transcription regulation path:  Phd1 --> Ste12 --> Dig1 --> Yap5 --> Mhp1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Red1 <-> Glc7 <-> Mhp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.047972
   Common cellular processes: Differentiation, Mitosis

Circuit 631: Phd1 Hxt3
   Transcription regulation path:  Phd1 --> Hxt3
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Pre2 <-> Std1 <-> Hxt3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.047784
   Common cellular processes: Carbohydrate metabolism, Small molecule transport

Circuit 632: Phd1 Smk1
   Transcription regulation path:  Phd1 --> Ste12 --> Sum1 --> Smk1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Srp1 <-> Qcr2 <-> Smk1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.042705
   Common cellular processes: Differentiation

Circuit 633: Phd1 Std1
   Transcription regulation path:  Phd1 --> Msn2 --> Yap6 --> Cin5 --> Std1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Pre2 <-> Std1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.033277
   Common cellular processes: Cell stress

Circuit 634: Phd1 Std1
   Transcription regulation path:  Phd1 --> Cup9 --> Yap6 --> Cin5 --> Std1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Pre2 <-> Std1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.033277
   Common cellular processes: Cell stress

Circuit 635: Phd1 Std1
   Transcription regulation path:  Phd1 --> Yap1 --> Yap6 --> Cin5 --> Std1
   Protein-protein interaction path: Phd1 <-> Smt3 <-> Pre2 <-> Std1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.033277
   Common cellular processes: Cell stress

Circuit 636: Skn7 Ime1
   Transcription regulation path:  Skn7 --> Sok2 --> Ime1
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Rif2 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 637: Skn7 Ime1
   Transcription regulation path:  Skn7 --> Nrg1 --> Ime1
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Rif2 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 638: Skn7 Ydj1
   Transcription regulation path:  Skn7 --> Rox1 --> Ume6 --> Hsf1 --> Ydj1
   Protein-protein interaction path: Skn7 <-> Crz1 <-> Nmd5 <-> Cln3 <-> Ydj1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.003605
   Common cellular processes: Cell stress

Circuit 639: Skn7 Yap1
   Transcription regulation path:  Skn7 --> Yap1
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Rif2 <-> Srb4 <-> Yap1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 640: Skn7 Cin5
   Transcription regulation path:  Skn7 --> Sok2 --> Yap6 --> Cin5
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Rif2 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 641: Skn7 Cin5
   Transcription regulation path:  Skn7 --> Nrg1 --> Yap6 --> Cin5
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Rif2 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 642: Skn7 Cin5
   Transcription regulation path:  Skn7 --> Yap1 --> Yap6 --> Cin5
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Rif2 <-> Srb4 <-> Cin5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 643: Skn7 Ssa1
   Transcription regulation path:  Skn7 --> Yap1 --> Ssa1
   Protein-protein interaction path: Skn7 <-> Crz1 <-> Nmd5 <-> Nup1 <-> Ssa1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.005514
   Common cellular processes: Cell stress

Circuit 644: Skn7 Dmc1
   Transcription regulation path:  Skn7 --> Rox1 --> Ume6 --> Dmc1
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Rif2 <-> Rdh54 <-> Dmc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.008771
   Common cellular processes: Meiosis

Circuit 645: Skn7 Nmd5
   Transcription regulation path:  Skn7 --> Yap1 --> Yap6 --> Cin5 --> Nmd5
   Protein-protein interaction path: Skn7 <-> Crz1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 2/2
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000000
   Common cellular processes: Cell stress

Circuit 646: Skn7 Tps1
   Transcription regulation path:  Skn7 --> Sok2 --> Msn4 --> Tps1
   Protein-protein interaction path: Skn7 <-> Crz1 <-> Nmd5 <-> Nup1 <-> Tps1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.002456
   Common cellular processes: Cell stress

Circuit 647: Skn7 Ptp2
   Transcription regulation path:  Skn7 --> Yap1 --> Ptp2
   Protein-protein interaction path: Skn7 <-> Cna1 <-> Smd3 <-> Slt2 <-> Ptp2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.005514
   Common cellular processes: Cell stress

Circuit 648: Ume6 Rpo21
   Transcription regulation path:  Ume6 --> Hsf1 --> Reb1 --> Rpo21
   Protein-protein interaction path: Ume6 <-> Ime1 <-> Srb4 <-> Gal11 <-> Rpo21
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 649: Ume6 Hop1
   Transcription regulation path:  Ume6 --> Hop1
   Protein-protein interaction path: Ume6 <-> Nup116 <-> Smt3 <-> Red1 <-> Hop1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001354
   Common cellular processes: Meiosis

Circuit 650: Ume6 Met18
   Transcription regulation path:  Ume6 --> Hsf1 --> Reb1 --> Swi5 --> Met18
   Protein-protein interaction path: Ume6 <-> Ime1 <-> Srb4 <-> Med11 <-> Met18
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004607
   Common cellular processes: Pol II transcription

Circuit 651: Ume6 Tfa2
   Transcription regulation path:  Ume6 --> Rme1 --> Tfa2
   Protein-protein interaction path: Ume6 <-> Ime1 <-> Srb4 <-> Gal11 <-> Tfa2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 652: Ume6 Taf12
   Transcription regulation path:  Ume6 --> Rme1 --> Taf12
   Protein-protein interaction path: Ume6 <-> Ime1 <-> Srb4 <-> Ngg1 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 653: Ume6 Taf12
   Transcription regulation path:  Ume6 --> Rme1 --> Taf12
   Protein-protein interaction path: Ume6 <-> Ime1 <-> Srb4 <-> Ada2 <-> Taf12
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 654: Pre2 Pso2
   Transcription regulation path:  Pre2 --> Gcn4 --> Pso2
   Protein-protein interaction path: Pre2 <-> Smt3 <-> Srp1 <-> Mcm21 <-> Pso2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.029176
   Common cellular processes: Protein degradation

Circuit 655: Pre2 Ahc1
   Transcription regulation path:  Pre2 --> Gcn4 --> Stb1 --> Ndd1 --> Ahc1
   Protein-protein interaction path: Pre2 <-> Std1 <-> Spt15 <-> Ada2 <-> Ahc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 656: Pre2 Ahc1
   Transcription regulation path:  Pre2 --> Gcn4 --> Stb1 --> Ndd1 --> Ahc1
   Protein-protein interaction path: Pre2 <-> Std1 <-> Taf9 <-> Ada2 <-> Ahc1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 657: Pre2 Mhp1
   Transcription regulation path:  Pre2 --> Gcn4 --> Yap5 --> Mhp1
   Protein-protein interaction path: Pre2 <-> Smt3 <-> Red1 <-> Glc7 <-> Mhp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.002456
   Common cellular processes: Mitosis

Circuit 658: Pre2 Cin8
   Transcription regulation path:  Pre2 --> Gcn4 --> Cin8
   Protein-protein interaction path: Pre2 <-> Smt3 <-> Nup116 <-> Spc72 <-> Cin8
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Centrosome/spindle pole body, Nuclear
   Circuit significance based on cellular process assessment: 0.002356
   Common cellular processes: Mitosis

Circuit 659: Pre2 Cdc20
   Transcription regulation path:  Pre2 --> Fkh2 --> Cdc20
   Protein-protein interaction path: Pre2 <-> Std1 <-> Ebs1 <-> Mad2 <-> Cdc20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Centrosome/spindle pole body, Nuclear
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 660: Pre2 Pds1
   Transcription regulation path:  Pre2 --> Fkh2 --> Pds1
   Protein-protein interaction path: Pre2 <-> Hmo1 <-> Msn5 <-> Nup84 <-> Pds1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.028274
   Common cellular processes: Cell cycle control

Circuit 661: Pre2 Rad16
   Transcription regulation path:  Pre2 --> Gcn4 --> Rad16
   Protein-protein interaction path: Pre2 <-> Smt3 <-> Hpr5 <-> Msl1 <-> Rad16
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017094
   Common cellular processes: DNA repair

Circuit 662: Pre2 Mlp2
   Transcription regulation path:  Pre2 --> Mlp2
   Protein-protein interaction path: Pre2 <-> Hmo1 <-> Msn5 <-> Nic96 <-> Mlp2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 663: Pre2 Mlp2
   Transcription regulation path:  Pre2 --> Mlp2
   Protein-protein interaction path: Pre2 <-> Smt3 <-> Nup116 <-> Kap95 <-> Mlp2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 664: Pre2 Sif2
   Transcription regulation path:  Pre2 --> Gcn4 --> Yap5 --> Sif2
   Protein-protein interaction path: Pre2 <-> Smt3 <-> Ris1 <-> Sir4 <-> Sif2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.028520
   Common cellular processes: Chromatin/chromosome structure

Circuit 665: Pre2 Ime1
   Transcription regulation path:  Pre2 --> Fkh2 --> Swi5 --> Rme1 --> Ime1
   Protein-protein interaction path: Pre2 <-> Std1 <-> Pop2 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 666: Pre2 Ime1
   Transcription regulation path:  Pre2 --> Fkh2 --> Ace2 --> Rme1 --> Ime1
   Protein-protein interaction path: Pre2 <-> Std1 <-> Pop2 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 667: Pre2 Pom152
   Transcription regulation path:  Pre2 --> Gcn4 --> Uga3 --> Pom152
   Protein-protein interaction path: Pre2 <-> Hmo1 <-> Msn5 <-> Nic96 <-> Pom152
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 668: Pre2 Pom152
   Transcription regulation path:  Pre2 --> Gcn4 --> Uga3 --> Pom152
   Protein-protein interaction path: Pre2 <-> Hmo1 <-> Msn5 <-> Nup188 <-> Pom152
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear pore
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 669: Mbp1 Cln3
   Transcription regulation path:  Mbp1 --> Swi4 --> Cln3
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc28 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000602
   Common cellular processes: Cell cycle control

Circuit 670: Mbp1 Cln3
   Transcription regulation path:  Mbp1 --> Swi4 --> Cln3
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Far1 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000602
   Common cellular processes: Cell cycle control

Circuit 671: Mbp1 Cln3
   Transcription regulation path:  Mbp1 --> Swi4 --> Cln3
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc53 <-> Cln3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000602
   Common cellular processes: Cell cycle control

Circuit 672: Mbp1 Las17
   Transcription regulation path:  Mbp1 --> Swi4 --> Sok2 --> Yap6 --> Las17
   Protein-protein interaction path: Mbp1 <-> Skn7 <-> Cna1 <-> Rvs161 <-> Las17
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic<=> Cytoskeletal
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 673: Mbp1 Spo13
   Transcription regulation path:  Mbp1 --> Abf1 --> Ume6 --> Spo13
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Hrr25 <-> Pfs1 <-> Spo13
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001855
   Common cellular processes: Meiosis

Circuit 674: Mbp1 Cdc7
   Transcription regulation path:  Mbp1 --> Cdc7
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc53 <-> Cdc7
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000702
   Common cellular processes: Cell cycle control

Circuit 675: Mbp1 Cdc24
   Transcription regulation path:  Mbp1 --> Abf1 --> Cdc24
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Far1 <-> Cdc24
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004913
   Common cellular processes: Cell cycle control

Circuit 676: Mbp1 Cdc6
   Transcription regulation path:  Mbp1 --> Cdc6
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc28 <-> Cdc6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Cell cycle control

Circuit 677: Mbp1 Clb5
   Transcription regulation path:  Mbp1 --> Clb5
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc28 <-> Clb5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Cell cycle control

Circuit 678: Mbp1 Lsm4
   Transcription regulation path:  Mbp1 --> Lsm4
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Hrr25 <-> Dcp1 <-> Lsm4
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification

Circuit 679: Mbp1 Cln1
   Transcription regulation path:  Mbp1 --> Cln1
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc28 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Cell cycle control

Circuit 680: Mbp1 Cln1
   Transcription regulation path:  Mbp1 --> Cln1
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Far1 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Cell cycle control

Circuit 681: Mbp1 Cln1
   Transcription regulation path:  Mbp1 --> Cln1
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc53 <-> Cln1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Cell cycle control

Circuit 682: Mbp1 Clb3
   Transcription regulation path:  Mbp1 --> Swi4 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc28 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 683: Mbp1 Clb3
   Transcription regulation path:  Mbp1 --> Swi4 --> Ndd1 --> Ace2 --> Clb3
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cks1 <-> Clb3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Complex<=> Complex
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 684: Mbp1 Clb1
   Transcription regulation path:  Mbp1 --> Clb1
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc28 <-> Clb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Cell cycle control

Circuit 685: Mbp1 Sic1
   Transcription regulation path:  Mbp1 --> Swi4 --> Ndd1 --> Swi5 --> Sic1
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc28 <-> Sic1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000000
   Common cellular processes: Cell cycle control

Circuit 686: Mbp1 Swi3
   Transcription regulation path:  Mbp1 --> Abf1 --> Swi3
   Protein-protein interaction path: Mbp1 <-> Skn7 <-> Cna1 <-> Rif2 <-> Swi3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012332
   Common cellular processes: Pol II transcription

Circuit 687: Mbp1 Cdc34
   Transcription regulation path:  Mbp1 --> Swi4 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Grr1 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 688: Mbp1 Cdc34
   Transcription regulation path:  Mbp1 --> Swi4 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Cln2 <-> Cdc53 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Cell cycle control

Circuit 689: Mbp1 Srp1
   Transcription regulation path:  Mbp1 --> Abf1 --> Srp1
   Protein-protein interaction path: Mbp1 <-> Swi6 <-> Ime2 <-> Smx3 <-> Srp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000150
   Common cellular processes: DNA synthesis

Circuit 690: Cin5 Aca1
   Transcription regulation path:  Cin5 --> Aca1
   Protein-protein interaction path: Cin5 <-> Srb4 <-> Yap6 <-> Gts1 <-> Aca1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000401
   Common cellular processes: Pol II transcription

Circuit 691: Cin5 Net1
   Transcription regulation path:  Cin5 --> Net1
   Protein-protein interaction path: Cin5 <-> Srb4 <-> Rif2 <-> Sir2 <-> Net1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear, Nuclear transport factor
   Circuit significance based on cellular process assessment: 0.007471
   Common cellular processes: Chromatin/chromosome structure

Circuit 692: Cin5 Mad2
   Transcription regulation path:  Cin5 --> Mad2
   Protein-protein interaction path: Cin5 <-> Srb4 <-> Gal11 <-> Sin4 <-> Mad2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.017449
   Common cellular processes: Pol II transcription

Circuit 693: Cin5 Nmd5
   Transcription regulation path:  Cin5 --> Nmd5
   Protein-protein interaction path: Cin5 <-> Srb4 <-> Crm1 <-> Nup1 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 694: Cin5 Nmd5
   Transcription regulation path:  Cin5 --> Nmd5
   Protein-protein interaction path: Cin5 <-> Srb4 <-> Crm1 <-> Nup159 <-> Nmd5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.012134
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 695: Cin5 Cln2
   Transcription regulation path:  Cin5 --> Rox1 --> Ume6 --> Rme1 --> Cln2
   Protein-protein interaction path: Cin5 <-> Zpr1 <-> Cln1 <-> Cdc28 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.020431
   Common cellular processes: Cell cycle control

Circuit 696: Cin5 Cln2
   Transcription regulation path:  Cin5 --> Rox1 --> Ume6 --> Rme1 --> Cln2
   Protein-protein interaction path: Cin5 <-> Zpr1 <-> Cln1 <-> Far1 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.020431
   Common cellular processes: Cell cycle control

Circuit 697: Cin5 Cln2
   Transcription regulation path:  Cin5 --> Rox1 --> Ume6 --> Rme1 --> Cln2
   Protein-protein interaction path: Cin5 <-> Zpr1 <-> Cln1 <-> Cdc53 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear
   Circuit significance based on cellular process assessment: 0.020431
   Common cellular processes: Cell cycle control

Circuit 698: Stb1 Pcl2
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Pcl2
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln1 <-> Pho85 <-> Pcl2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control

Circuit 699: Stb1 Ime1
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Rme1 --> Ime1
   Protein-protein interaction path: Stb1 <-> Sin3 <-> Ume6 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 700: Stb1 Ime1
   Transcription regulation path:  Stb1 --> Ndd1 --> Ace2 --> Rme1 --> Ime1
   Protein-protein interaction path: Stb1 <-> Sin3 <-> Ume6 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 3/3
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.035513
   Common cellular processes: Pol II transcription

Circuit 701: Stb1 Pcl9
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Pcl9
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln1 <-> Pho85 <-> Pcl9
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control

Circuit 702: Stb1 Pcl1
   Transcription regulation path:  Stb1 --> Pcl1
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln1 <-> Pho85 <-> Pcl1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.010128
   Common cellular processes: Cell cycle control

Circuit 703: Stb1 Dal80
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Gat1 --> Dal80
   Protein-protein interaction path: Stb1 <-> Sin3 <-> Lsm4 <-> Gzf3 <-> Dal80
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004607
   Common cellular processes: Pol II transcription

Circuit 704: Stb1 Dal80
   Transcription regulation path:  Stb1 --> Ndd1 --> Ace2 --> Gat1 --> Dal80
   Protein-protein interaction path: Stb1 <-> Sin3 <-> Lsm4 <-> Gzf3 <-> Dal80
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004607
   Common cellular processes: Pol II transcription

Circuit 705: Stb1 Cdc34
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cdc6 <-> Cdc4 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control

Circuit 706: Stb1 Cdc34
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln3 <-> Cdc53 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control

Circuit 707: Stb1 Cdc34
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln1 <-> Cdc53 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control

Circuit 708: Stb1 Cdc34
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln2 <-> Grr1 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control

Circuit 709: Stb1 Cdc34
   Transcription regulation path:  Stb1 --> Ndd1 --> Swi5 --> Cdc34
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln2 <-> Cdc53 <-> Cdc34
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.001754
   Common cellular processes: Cell cycle control

Circuit 710: Stb1 Cdc20
   Transcription regulation path:  Stb1 --> Ndd1 --> Cdc20
   Protein-protein interaction path: Stb1 <-> Cdc28 <-> Cln3 <-> Mad3 <-> Cdc20
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000602
   Common cellular processes: Cell cycle control

Circuit 711: Stb1 Htb1
   Transcription regulation path:  Stb1 --> Ndd1 --> Ace2 --> Spt4 --> Htb1
   Protein-protein interaction path: Stb1 <-> Sin3 <-> Lsm4 <-> Snf5 <-> Htb1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.027141
   Common cellular processes: Pol II transcription

Circuit 712: Gcr2 Prp22
   Transcription regulation path:  Gcr2 --> Prp22
   Protein-protein interaction path: Gcr2 <-> Snp1 <-> Prp8 <-> Msl5 <-> Prp22
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 713: Gcr2 Prp22
   Transcription regulation path:  Gcr2 --> Prp22
   Protein-protein interaction path: Gcr2 <-> Snp1 <-> Brr2 <-> Slu7 <-> Prp22
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 714: Dig1 Msh5
   Transcription regulation path:  Dig1 --> Mss11 --> Msh5
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Rad51 <-> Cst9 <-> Msh5
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000802
   Common cellular processes: Recombination

Circuit 715: Dig1 Pup3
   Transcription regulation path:  Dig1 --> Ste12 --> Pup3
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup116 <-> Pup1 <-> Pup3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Endoplasmatic reticulum, Nuclear
   Circuit significance based on cellular process assessment: 0.001855
   Common cellular processes: Protein degradation

Circuit 716: Dig1 Top1
   Transcription regulation path:  Dig1 --> Mss11 --> Rox1 --> Ume6 --> Top1
   Protein-protein interaction path: Dig1 <-> Ste12 <-> Matalpha1 <-> Matalpha2 <-> Top1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004507
   Common cellular processes: Differentiation

Circuit 717: Dig1 Top1
   Transcription regulation path:  Dig1 --> Mss11 --> Rox1 --> Ume6 --> Top1
   Protein-protein interaction path: Dig1 <-> Ste12 <-> Mcm1 <-> Matalpha2 <-> Top1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004507
   Common cellular processes: Differentiation

Circuit 718: Dig1 Lsm3
   Transcription regulation path:  Dig1 --> Ste12 --> Swi5 --> Lsm3
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Mcm21 <-> Smb1 <-> Lsm3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.028520
   Common cellular processes: Chromatin/chromosome structure

Circuit 719: Dig1 Bud14
   Transcription regulation path:  Dig1 --> Bud14
   Protein-protein interaction path: Dig1 <-> Ady3 <-> Spo21 <-> Glc7 <-> Bud14
   Circuit significance based on cellular process assessment: 0.003911
   Common cellular processes: Differentiation
   Circuit significance based on results of knockout experiments: 0.0001
   Circuit potential targets: Fus3 up, Fus1 up, Afr1 up, Ssf2 up, Yer138c up, Yer160c up, Msb2 up, Crh1 up, Cwp1 up, Pry2 up, Ktr2 up, Srl3 up, Ymr045c up, Ymr046c up, Yer159c-a up, Ygp1 down, Svs1 up.

Circuit 720: Dig1 Ste3
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Ste3
   Protein-protein interaction path: Dig1 <-> Kss1 <-> Ste5 <-> Akr1 <-> Ste3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Plasma membrane<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.000150
   Common cellular processes: Mating response, Signal transduction

Circuit 721: Dig1 Ste3
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Ste3
   Protein-protein interaction path: Dig1 <-> Fus3 <-> Ste5 <-> Akr1 <-> Ste3
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Plasma membrane<=> Plasma membrane
   Circuit significance based on cellular process assessment: 0.000150
   Common cellular processes: Mating response, Signal transduction

Circuit 722: Dig1 Cln2
   Transcription regulation path:  Dig1 --> Ste12 --> Swi5 --> Ash1 --> Cln2
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Bmh1 <-> Ste20 <-> Cln2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.000100
   Common cellular processes: Differentiation

Circuit 723: Dig1 Lsm6
   Transcription regulation path:  Dig1 --> Lsm6
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Smx3 <-> Smd2 <-> Lsm6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009226
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 724: Dig1 Rpb2
   Transcription regulation path:  Dig1 --> Hrt1 --> Sfp1 --> Rpb2
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup1 <-> Rpo26 <-> Rpb2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.013784
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 725: Dig1 Rck1
   Transcription regulation path:  Dig1 --> Ste12 --> Rck1
   Protein-protein interaction path: Dig1 <-> Kss1 <-> Ste11 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.002607
   Common cellular processes: Signal transduction

Circuit 726: Dig1 Rck1
   Transcription regulation path:  Dig1 --> Ste12 --> Rck1
   Protein-protein interaction path: Dig1 <-> Fus3 <-> Ste11 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.002607
   Common cellular processes: Signal transduction

Circuit 727: Dig1 Rck1
   Transcription regulation path:  Dig1 --> Ste12 --> Rck1
   Protein-protein interaction path: Dig1 <-> Fus3 <-> Ptp3 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.002607
   Common cellular processes: Signal transduction

Circuit 728: Dig1 Srv2
   Transcription regulation path:  Dig1 --> Mss11 --> Srv2
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Arp2 <-> Abp1 <-> Srv2
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoskeletal<=> Cytoskeletal
   Circuit significance based on cellular process assessment: 0.000952
   Common cellular processes: Cell structure

Circuit 729: Dig1 Rpl16a
   Transcription regulation path:  Dig1 --> Yap5 --> Rpl16a
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup57 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 730: Dig1 Rpl16a
   Transcription regulation path:  Dig1 --> Yap5 --> Rpl16a
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup100 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 731: Dig1 Rpl16a
   Transcription regulation path:  Dig1 --> Yap5 --> Rpl16a
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup116 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 732: Dig1 Rpl16a
   Transcription regulation path:  Dig1 --> Yap5 --> Rpl16a
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup1 <-> Sxm1 <-> Rpl16a
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear, Nuclear pore<=> Cytoplasmic
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 733: Dig1 Ksp1
   Transcription regulation path:  Dig1 --> Ste12 --> Ksp1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Gsp1 <-> Crm1 <-> Ksp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 734: Dig1 Ksp1
   Transcription regulation path:  Dig1 --> Ste12 --> Ksp1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup57 <-> Crm1 <-> Ksp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 735: Dig1 Ksp1
   Transcription regulation path:  Dig1 --> Ste12 --> Ksp1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup49 <-> Crm1 <-> Ksp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 736: Dig1 Ksp1
   Transcription regulation path:  Dig1 --> Ste12 --> Ksp1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup100 <-> Crm1 <-> Ksp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 737: Dig1 Ksp1
   Transcription regulation path:  Dig1 --> Ste12 --> Ksp1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup116 <-> Crm1 <-> Ksp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 738: Dig1 Ksp1
   Transcription regulation path:  Dig1 --> Ste12 --> Ksp1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Nup1 <-> Crm1 <-> Ksp1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear, Nuclear pore<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.011129
   Common cellular processes: Nuclear-cytoplasmic transport

Circuit 739: Dig1 Ime1
   Transcription regulation path:  Dig1 --> Ste12 --> Swi5 --> Rme1 --> Ime1
   Protein-protein interaction path: Dig1 <-> Ste12 <-> Mcm1 <-> Srb4 <-> Ime1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004607
   Common cellular processes: Pol II transcription

Circuit 740: Dig1 Pfs1
   Transcription regulation path:  Dig1 --> Ste12 --> Sum1 --> Pfs1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Rad51 <-> Hrr25 <-> Pfs1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.004010
   Common cellular processes: Differentiation

Circuit 741: Dig1 Hop1
   Transcription regulation path:  Dig1 --> Mss11 --> Rox1 --> Ume6 --> Hop1
   Protein-protein interaction path: Dig1 <-> Srp1 <-> Smt3 <-> Red1 <-> Hop1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.009514
   Common cellular processes: Meiosis

Circuit 742: Nrg1 Std1
   Transcription regulation path:  Nrg1 --> Yap6 --> Cin5 --> Std1
   Protein-protein interaction path: Nrg1 <-> Cyc8 <-> Mig1 <-> Snf1 <-> Std1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Cytoplasmic, Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.010025
   Common cellular processes: Pol II transcription

Circuit 743: Aro80 Lsm6
   Transcription regulation path:  Aro80 --> Lsm6
   Protein-protein interaction path: Aro80 <-> Prp9 <-> Prp11 <-> Lsm4 <-> Lsm6
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Nuclear<=> Nuclear<=> Nuclear
   Circuit significance based on cellular process assessment: 0.000652
   Common cellular processes: RNA processing/modification, RNA splicing

Circuit 744: Rlm1 Fks1
   Transcription regulation path:  Rlm1 --> Fks1
   Protein-protein interaction path: Rlm1 <-> Slt2 <-> Mkk1 <-> Pkc1 <-> Fks1
   Circuit significance based on cellular process assessment: 0.014089
   Common cellular processes: Cell stress, Cell wall maintenance, Signal transduction
   Circuit significance based on results of knockout experiments: 0.0001
   Circuit potential targets: Pst1 up, Sed1 up, Afr1 up, Crh1 up, Cis3 up, Hsp150 up, Cwp1 up, Pir3 up, Ktr2 up, Srl3 up, Ylr194c up, Ccw14 up, Dfg5 up, Yik8_yeast up.

Circuit 745: Rlm1 Rck1
   Transcription regulation path:  Rlm1 --> Rck1
   Protein-protein interaction path: Rlm1 <-> Slt2 <-> Ptp2 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic, Nuclear<=> Cytoplasmic, Nuclear<=> Complex
   Circuit significance based on cellular process assessment: 0.014089
   Common cellular processes: Cell stress, Signal transduction

Circuit 746: Rlm1 Rck1
   Transcription regulation path:  Rlm1 --> Rck1
   Protein-protein interaction path: Rlm1 <-> Slt2 <-> Ptp3 <-> Hog1 <-> Rck1
   Fraction of feasible interactions out of the total number of protein-protein interactions: 4/4
   Co-localization path of physically interacting pair-mates:  Nuclear<=> Cytoplasmic<=> Cytoplasmic<=> Complex
   Circuit significance based on cellular process assessment: 0.014089
   Common cellular processes: Cell stress, Signal transduction


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