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Hanah Margalit's Lab

Department of Microbiology and Molecular Genetics
Faculty of Medicine
The Hebrew University of Jerusalem


We study regulation of gene expression by non-coding RNAs (small RNAs (sRNAs) in bacteria and miRNAs in eukaryotes), and its integration with transcription regulation and protein-protein interactions.

Our laboratory is interdisciplinary, combining state-of-the-art wet-lab experiments with advanced computational analyses.

Our projects include: deciphering sRNA-target interactions at a transcriptome-wide scale; implications of competition between target mRNAs over binding to their sRNA (miRNA) co-regulator; regulatory circuits involving small RNAs and transcription factors; new mechanisms of action of miRNAs and sRNAs; involvement of miRNAs in virus-host interaction; cleavage patterns of RNA nucleases in the cell.

The projects in the lab are conducted either by lab members with interdisciplinary background in computer science and life sciences, or by fruitful collaborations between lab members with complementary backgrounds in life sciences, medical sciences, computer science, and physics.